(2S,3S)- 3-hydroxy-2-Pyrrolidinemethanol hydrochloride

Base Information

• Chemical Name: (2S,3S)- 3-hydroxy-2-Pyrrolidinemethanol hydrochloride
• CAS No.: 154278-84-9
• Molecular Formula: C5H11NO2.HCl
• Molecular Weight: 153.60728
• Mol file: 154278-84-9.mol

Synonyms:(2S,3S)- 3-hydroxy-2-PyrrolidineMethanol hydrochloride

Chemical Property of (2S,3S)- 3-hydroxy-2-Pyrrolidinemethanol hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)- 3-hydroxy-2-Pyrrolidinemethanol hydrochloride

There total 70 articles about (2S,3S)- 3-hydroxy-2-Pyrrolidinemethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2R,3S)-tert-butyl 3-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate (156129-72-5) → (2R,3S)-2-hydroxymethyl-3-hydroxypyrrolidinium hydrochloride (98900-30-2,154278-84-9,159912-46-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 2h;

Reference yield: 100.0%

3,5-di-O-benzyl-1,2,4-trideoxy-1,4-imino-D-erythro-pentitol (294188-28-6) → (2R,3S)-2-hydroxymethyl-3-hydroxypyrrolidinium hydrochloride (98900-30-2,154278-84-9,159912-46-6)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 24h; under 760 Torr;

DOI:10.1080/07328300008544100

Reference yield: 100.0%

(2R,3R)-1-(tert-Butoxycarbonyl)-2.(hydroxymethyl)-3-hydroxypyrrolidine (130193-02-1) → (2R,3R)-2-(hydroxymethyl)pyrrolidin-3-ol hydrochloride (154278-84-9,159912-46-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 2h;

upstream raw materials:

(2R,3S)-3-Hydroxy-2-hydroxymethyl-pyrrolidine-1-carboxylic acid methyl ester

(2R,3S)-tert-butyl 3-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

(2R,3S)-N-benzyl-3-hydroxy-2-hydroxymethylpyrrolidine

(4aR,7aS)-2,2-Dimethyl-tetrahydro-[1,3]dioxino[5,4-b]pyrrole-5-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "7-SUBSTITUTED 1-ARYL-NAPHTHYRIDINE-3-CARBOXYLIC ACID AMIDES AND USE THEREOF". Paragraph 0831-0833. . Retrieved 2019/09/06.
• 2、 -. "DIFLUOROPYRROLIDINES AS OREXIN RECEPTOR MODULATORS". . . Retrieved 2016/02/29.