154318-44-2

Basic information

• Product Name: (1R)-1-(1-naphthyl)-N-(phenylmethylene)ethanamine
• Synonyms: (1R)-1-(1-naphthyl)-N-(phenylmethylene)ethanamine
• CAS NO: 154318-44-2
• Molecular Weight: 259.351
• Mol File: 154318-44-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (1R)-1-(1-naphthyl)-N-(phenylmethylene)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-1-(1-naphthyl)-N-(phenylmethylene)ethanamine(154318-44-2)
• EPA Substance Registry System: (1R)-1-(1-naphthyl)-N-(phenylmethylene)ethanamine(154318-44-2)

Safety Data

• Hazardous Substances Data: 154318-44-2(Hazardous Substances Data)

Upstream product

• 3886-70-2 (R)-1-(1-Naphthyl)ethylamine 
• 100-52-7 benzaldehyde 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1271930-15-4 (R)-(1-naphthalen-1-ylethyl)-N,N-bis[3-(3-trifluoromethylphenyl)propyl]amine 
• 66469-40-7 N‐benzyl‐1‐(1‐naphthyl)ethylamine 
• 364782-34-3 cinacalcet hydrochloride 
• 226256-56-0 cinacalcet 
• 1245374-92-8 cinacalcet base 

Relevant articles and documents

In Situ Generated Cobalt Catalyst for the Dehydrogenative Coupling of Alcohols and Amines into Imines

An in situ formed cobalt catalyst is developed from cobalt(II)bromide, bis[2-(diisopropylphosphino)-4-methylphenyl]amine and zinc metal. The catalyst mediates the acceptorless dehydrogenative coupling of alcohols and amines into imines with the release of hydrogen gas and the transformation is applied to the synthesis of a variety of imines from different alcohols and amines. The mechanism is investigated with labelled substrates and based on the results a cobalt(I) PNP complex is believed to be the catalytically active species which abstracts hydrogen gas from the alcohol through a metal ligand bifunctional pathway.

Molybdenum-Catalyzed Dehydrogenative Synthesis of Imines from Alcohols and Amines

A molybdenum N-heterocyclic carbene catalyst has been developed for the synthesis of imines from primary alcohols and amines with the liberation of dihydrogen. The catalyst is generated in situ from molybdenum hexacarbonyl, 1,3-dicyclohexylimidazolium chloride and potassium tert-butoxide and is further stabilized by the phosphine ligand dppe. Imines are formed in moderate to good isolated yields and a variety of alcohols and amines can be employed in the reaction including anilines. The transformation constitutes the first example of a homogeneous molybdenum-catalyzed acceptorless dehydrogenative coupling with alcohols and is believed to proceed by formation of a cis-coordinated molybdenum bis-N-heterocyclic carbene complex, which performs an oxidative addition to the alcohol, β-hydride elimination and reductive elimination of dihydrogen.

An investigation towards the diastereoselective synthesis of 3-acetoxy/methoxy/phthalimido-β-lactams using chiral imines

The efficient diastereoselective synthesis of 3-acetoxy/methoxy/phthalimido-β-lactams 2/2′, 3/3′ and 4/4′ respectively was performed using chiral imines 1 obtained from chiral amines. Factors (solvent, temperature, substituent, steric bulk) influencing th