154327-28-3

Basic information

• Product Name: 2-CHLORO-7-FLUOROBENZOTHIAZOLE
• Synonyms: 2-CHLORO-7-FLUOROBENZOTHIAZOLE;2-Chloro-7-fluorobenzo[d]thiazole;Benzothiazole, 2-chloro-7-fluoro-
• CAS NO: 154327-28-3
• Molecular Formula: C₇H₃ClFNS
• Molecular Weight: 187.62
• Mol File: 154327-28-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 253.0±13.0 °C(Predicted)
• Appearance: /
• Density: 1.532±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.07±0.30(Predicted)
• CAS DataBase Reference: 2-CHLORO-7-FLUOROBENZOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-7-FLUOROBENZOTHIAZOLE(154327-28-3)
• EPA Substance Registry System: 2-CHLORO-7-FLUOROBENZOTHIAZOLE(154327-28-3)

Safety Data

• Hazardous Substances Data: 154327-28-3(Hazardous Substances Data)

Usage

General Description

2-Chloro-7-fluorobenzothiazole is a chemical compound with the molecular formula C7H3ClFS. It is a heterocyclic organic compound that consists of a benzene ring fused to a thiazole ring with a chloro and a fluoro substituent attached to it. 2-CHLORO-7-FLUOROBENZOTHIAZOLE has potential applications in the pharmaceutical and agricultural industries as a building block for the synthesis of various biologically active compounds. Due to its structural and electronic properties, 2-Chloro-7-fluorobenzothiazole has also been studied for its potential use in organic electronic devices and materials. Overall, this compound has shown promise for various applications, making it a subject of interest in the fields of chemistry, pharmaceuticals, and materials science.

Upstream product

• 154327-29-4 2-mercapto-7-fluorobenzothiazole 
• 4519-40-8 2,3-difluoroanilline 
• 140-89-6 potassium ethyl xanthogenate 

Relevant articles and documents

A convenient synthesis of 2-mercapto and 2-chlorobenzothiazoles

A convenient synthesis of 2-mercapto and 2-chlorobenzothiazoles is described. The key feature of the synthesis is an exclusive ortho-selective nucleophilic aromatic substitution reaction of ortho-haloanilines with potassium/sodium O-ethyl dithiocarbonate under mild conditions. Subsequent intra-molecular cyclization affords 2-mercaptobenzothiazoles in high yields. The 2-mercaptobenzothiazoles are readily converted to corresponding 2-chlorobenzothiazoles upon treatment with sulfuryl chloride.

Novel Triapine Derivative Induces Copper-Dependent Cell Death in Hematopoietic Cancers

Triapine, an iron chelator that inhibits ribonucleotide reductase, has been evaluated in clinical trials for cancer treatment. Triapine in combination with other chemotherapeutic agents shows promising efficacy in certain hematologic malignancies; however, it is less effective against many advanced solid tumors, probably due to the unsatisfactory potency and pharmacokinetic properties. In this report, we developed a triapine derivative IC25 (10) with potent antitumor activity. 10 Preferentially inhibited the proliferation of hematopoietic cancers by inducing mitochondria reactive oxygen species production and mitochondrial dysfunction. Unlike triapine, 10 executed cytotoxic action in a copper-dependent manner. 10-Induced up-expression of thioredoxin-interacting protein resulted in decreased thioredoxin activity to permit c-Jun N-terminal kinase and p38 activation and ultimately led to the execution of the cell death program. Remarkedly, 10 showed good bioavailability and inhibited tumor growth in mouse xenograft models. Taken together, our study identifies compound 10 as a copper-dependent antitumor agent, which may be applied to the treatment of hematopoietic cancers.

BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME

The present invention provides a benzo[d]thiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The benzo[d]thiazole derivative or its pharmaceutically acce