154343-54-1

Basic information

• Product Name: 2-CHLORO-5,8-DIMETHOXY-3-PHENYLQUINOLINE
• Synonyms: 2-CHLORO-5,8-DIMETHOXY-3-PHENYLQUINOLINE
• CAS NO: 154343-54-1
• Molecular Formula: C₁₇H₁₄ClNO₂
• Molecular Weight: 299.75
• Mol File: 154343-54-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CHLORO-5,8-DIMETHOXY-3-PHENYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5,8-DIMETHOXY-3-PHENYLQUINOLINE(154343-54-1)
• EPA Substance Registry System: 2-CHLORO-5,8-DIMETHOXY-3-PHENYLQUINOLINE(154343-54-1)

Safety Data

• Hazardous Substances Data: 154343-54-1(Hazardous Substances Data)

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 154343-49-4 N-(2',5'-dimethoxyphenyl)-2-phenylacetamide 
• 79-16-3 N-methyl-acetamide 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 154343-46-1 3-phenyl-2,5,8(1H)-quinolinetrione 
• 154343-56-3 3-phenyl-5,8-dimethoxy-2(1H)-quinolinone 

Relevant articles and documents

Anthraquinonic derivatives having an antitumor activity and applications thereof

Said derivatives have the general formula (I) and are: STR1 (I-A) 4,6,7-trimethyl-5,8,8a,10a-tetrahydro-1H-1-azaanthracen-2,9,10-trione; (I-B) 2-ethoxy-3-methyl-1-azaanthracen-9,10-dione; (I-C) 3-ethyl-1,8-dihydro-1H-1,8-diazaanthracen-2,7,9,10-tetraone;

SYNTHESIS OF 2,5,8(1H)-QUINOLINETRIONE DERIVATIVES THROUGH VILSMEIER-HAACK FORMYLATION OF 2,5-DIMETHOXYANILIDES

The preparation of 2,5,8(1H)-quinolinetrione derivatives bearing both electron-withdrawing and electron-releasing groups at C3 is described.The reaction sequence employed involves Vilsmeier-Haack cyclization of 2,5-dimethoxyanilides into 3-substituted 5,8-dimethoxy-2-chloroquinolinolines, followed by hydrolysis to the corresponding 2(1H)-quinolinones and oxidative demethylation with cerium ammonium nitrate.