154344-45-3

Basic information

• Product Name: 2-phenethylisothiazolo<5,4-b>pyridin-3(2H)-one
• CAS NO: 154344-45-3
• Molecular Weight: 256.328
• Mol File: 154344-45-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-phenethylisothiazolo<5,4-b>pyridin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenethylisothiazolo<5,4-b>pyridin-3(2H)-one(154344-45-3)
• EPA Substance Registry System: 2-phenethylisothiazolo<5,4-b>pyridin-3(2H)-one(154344-45-3)

Safety Data

• Hazardous Substances Data: 154344-45-3(Hazardous Substances Data)

Upstream product

• 65282-42-0 1,2-dithiolo<5,4-b>pyridin-3-one 
• 330667-57-7 2-mercapto-N-pentyl-nicotinamide 
• 154344-30-6 2-pentylisothiazolo<5,4-b>pyridine-3(2H)-thione 
• 154344-43-1 2-pentylisothiazolo<5,4-b>pyridin-3(2H)-one 
• 154344-24-8 2-Mercapto-N-pentyl-thionicotinamide 
• 330667-58-8 2-mercapto-N-phenethyl-nicotinamide 
• 154344-33-9 2-phenylethylisothiazolo<5,4-b>pyridine-3(2H)-thione 

Downstream Products

• 154344-33-9 2-phenylethylisothiazolo<5,4-b>pyridine-3(2H)-thione 
• 330667-58-8 2-mercapto-N-phenethyl-nicotinamide 
• 91859-66-4 2-benzylisothiazolo<5,4-b>pyridin-3(2H)-one 
• 3445-78-1 3H-1,2-dithiolo<3,4-b>pyridine-3-thione 
• 65282-42-0 1,2-dithiolo<5,4-b>pyridin-3-one 
• 330667-59-9 2-mercapto-N-(3-phenyl-propyl)-nicotinamide 
• 91859-79-9 N-Benzyl-2-mercapto-nicotinamide 
• 154344-34-0 2-(3-phenylpropyl)isothiazolo<5,4-b>pyridine-3(2H)-thione 
• 154344-46-4 2-(3-phenylpropyl)isothiazolo<5,4-b>pyridin-3(2H)-one 
• 154344-32-8 2-benzylisothiazolo<5,4-b>pyridine-3(2H)-thione 
• 154344-28-2 2-Mercapto-N-(3-phenyl-propyl)-thionicotinamide 

Relevant articles and documents

3H-[1,2]Dithiolo[3,4-b]pyridine-3-thione and its derivatives. Synthesis and antimicrobial activity

A series of 2-substituted isothiazolo[5,4-b]pyridine-3(2H)-thiones, isothiazolo[5,4-b]pyridin-3(2H)-ones, N-substituted 2-sulfanylnicotinamides and the corresponding carbothioamide derivatives were synthesized and evaluated for their antimicrobial activity against several strains of Gram+ and Gram-bacteria and fungi. Chemical syntheses were resumed into a comprehensive cyclic route that enables the reversible conversion for each derivative of the series considered. Among the tested compounds the N-(aralkyl)-2-sulfanylnicotinamides show the highest fungitoxicity (MIC=1.25-5 μg/ml). The best activity towards Gram-positive bacteria was in the range of 2.5-5 μg/ml. Activity against Gram-negative bacteria was generally very poor for all compounds. Copyright