154352-43-9Relevant articles and documents
SUBSTITUTED BENZIMIDAZOLES AND QUINAZOLINES AS ANTIHYPERTENSIVES
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, (2008/06/13)
There are disclosed compounds of the formula STR1 wherein R 1 is STR2 R 2 is STR3 wherein X is STR4 wherein R. sup.5 is hydrogen, alkyl of 1-6 carbon atoms, benzyl, triphenylmethyl, or Sn(alkyl of 1-6 carbon atoms) 3 ;n is 1 to 3;Y is STR5 wherein R 3 is hydrogen, perfluoro alkyl of 1-6 carbon atoms, trifluoromethylalkyl of 1-6 carbon atoms, or alkyl of 1-6 carbon atoms; and R 4 is hydrogen or alkyl of 1-6 carbon atoms; with the proviso that when R 1 is STR6 then R. sup.2 cannot be STR7 wherein X is as defined above; and the pharmaceutically acceptable salts thereof, which by virtue of their ability to antagonize angiotensin II are useful for the treatment of hypertension and congestive heart-failure.