5465-29-2

Basic information

• Product Name: 2-Propylbenzimidazole
• Synonyms: 1H-Benzimidazole,2-propyl-(9CI);2-Propyl-1H-benzimidazole;2-Propylbenzimidazole;2-propyl-1H-benzo[d]imidazole;2-propyl-1H-1,3-benzodiazole;2-propylbenzIMIDAZOLE:2-propyl-1h-benzIMIDAZOLE;OMSTint-A
• CAS NO: 5465-29-2
• Molecular Formula: C₁₀H₁₂N₂
• Molecular Weight: 160.22
• Product Categories: BENZIMIDAZOLE
• Mol File: 5465-29-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 152-153 °C
• Boiling Point: 348.8 °C at 760 mmHg
• Flash Point: 179.4 °C
• Appearance: /
• Density: 1.109 g/cm³
• Vapor Pressure: 9.87E-05mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.99±0.10(Predicted)
• CAS DataBase Reference: 2-Propylbenzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propylbenzimidazole(5465-29-2)
• EPA Substance Registry System: 2-Propylbenzimidazole(5465-29-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5465-29-2(Hazardous Substances Data)

Usage

Uses

2-Propylbenzimidazole is a reagent used in the synthesis of novel benzimidazole analogs.

InChI:InChI=1/C10H12N2/c1-2-5-10-11-8-6-3-4-7-9(8)12-10/h3-4,6-7H,2,5H2,1H3,(H,11,12)

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 71-36-3 butan-1-ol 
• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 19591-17-4 o-iodoacetanilide 
• 3020-81-3 butylamidine hydrochloride 
• 614-76-6 N-acetyl-2-bromoaniline 
• 862898-37-1 N-(2-diphenylacetylaminophenyl)butyramide 
• 41501-57-9 propyl 2,2-dichlorovinyl ketone 

Downstream Products

• 570-22-9 4,5-imidazoledicarboxylic acid 
• 58954-23-7 2-propyl-1H-imidazole-4,5-dicarboxylic acid 
• 95320-21-1 1-benzyl-2-propyl-1H-benzoimidazole 
• 133141-63-6 4’-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1’-biphenyl]-2-carboxylicacid 
• 1560633-45-5 3-[2-(2-propyl-1H-benzimidazol-1-yl)acetyl]benzenesulfonamide 
• 1560633-42-2 2-chloro-4-[2-(2-propyl-1H-benzimidazol-1-yl)acetyl]benzenesulfonamide 
• 1560633-41-1 4-[2-(2-propyl-1H-benzimidazol-1-yl)acetyl]benzenesulfonamide 
• 46192-58-9 5-amino-2-propyl benzimidazole 
• 1247725-65-0 C₁₇H₁₇BrN₂ 

Relevant articles and documents

Ag-TiO2/clay composite photocatalyst for the oxidation-cyclization of 1,2-diamine compounds with propylene glycol or alcohols

Silver-loaded TiO2 (Ag-TiO2) and acidic clay (K10 montmorillonite) composite photocatalyst has been successfully applied for the light-induced conversion of o-phenylenediamine (OPD) and its derivatives to substituted benzimidazoles with various alcohols in acetonitrile using UV-A and solar light. The influence of the various photocatalysts, solvents, and substituents on the yield and selectivity of the products has been investigated. The mechanism of photocatalysis is proposed. Loading silver on TiO2 enhances product yield and selectivity both in UV and solar light. In the presence of primary alcohols, 2-aminothiophenol forms only disulfide and hence Ag-TiO2/ clay can be used as a green catalyst for the synthesis of disulfides.

Conversion of sterically hindered diacylated 1,2-phenylenediamines into 2-substituted benzimidazoles

A series of bulky 2-substituted benzimidazoles was designed in order to find new leads for several biological targets. Formation by cyclodehydration from their monoacylated counterparts was shown to be strongly dependent upon the nature of the acyl group. In the case of a dicyclohexylmethyl group, cycllzation was only observed in a p-toluenesulfonic acid/toluene mixture from the symmetrical diacylated precursor. Analysis of the mechanism was begun starting from mixed diacylated derivatives.