154355-80-3

Basic information

• Product Name: Furan, 2-[(4-fluorophenyl)methyl]-
• CAS NO: 154355-80-3
• Molecular Formula: C11H9FO
• Molecular Weight: 176.19
• Mol File: 154355-80-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Furan, 2-[(4-fluorophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Furan, 2-[(4-fluorophenyl)methyl]-(154355-80-3)
• EPA Substance Registry System: Furan, 2-[(4-fluorophenyl)methyl]-(154355-80-3)

Safety Data

• Hazardous Substances Data: 154355-80-3(Hazardous Substances Data)

Upstream product

• 110-00-9 furan 
• 459-46-1 4-Fluorobenzyl bromide 
• 403-43-0 4-fluorobenzoyl chloride 
• 352-34-1 4-fluoro-1-iodobenzene 
• 98-00-0 (2-furyl)methyl alcohol 

Downstream Products

• 154355-81-4 2-Bromo-5-(4-fluorophenylmethyl)furan 

Relevant articles and documents

Intra- and Intermolecular Nickel-Catalyzed Reductive Cross-Electrophile Coupling Reactions of Benzylic Esters with Aryl Halides

Nickel-catalyzed cross-electrophile coupling reactions of benzylic esters and aryl halides have been developed. Both inter- and intramolecular variants proceed under mild reaction conditions. A range of heterocycles and functional groups are tolerated under the reaction conditions. Additionally, the first example of a stereospecific cross-electrophile coupling of a secondary benzylic ester is described. Crossed off: Nickel-catalyzed cross-electrophile coupling reactions of benzylic esters and aryl halides have been developed. Both inter- and intramolecular variants proceed under mild reaction conditions, and a range of heterocycles and functional groups are tolerated. Additionally, the first example of a stereospecific cross-electrophile coupling of a secondary benzylic ester is described.

Substituted arylalkynyl-and heteroarylalkynl-N-hydroxyurea inhibitors of leukotriene biosynthesis

The invention relates to compounds having activity to inhibit lipoxygenase enzyme activity, to pharmaceutical compositions comprising these compounds, and to a medical method of treating. More particularly, this invention concerns certain substituted arylalkynyl- and ((heteroaryl)alkynyl)-N-hydroxy-ureas which inhibit leukotriene biosynthesis, to pharmaceutical compositions of these compounds and to a method of inhibiting leukotriene biosynthesis.

[(SUBSTITUTED) PHENYALKYL]FURYLALKYNYL-AND [SUBSTITUTED)PHENYALKYL]THIENYLALKYNYL-N-HYDROXYUREA INHIBITORS OR LEUKOTRIENE BIOSYNTHESIS

The present invention relates to compounds of the formula and the pharmaceutically acceptable salts thereof wherein Z is selected from optionally substituted phenyl, furyl, thienyl or thiazolyl; which inhibits leukotriene biosynthesis and is useful in the treatment of inflammatory disease states; also disclosed are leukotriene biosynthesis inhibiting compositions and a method for inhibiting 5-lipoxygenase activity and leukotriene biosynthesis