154365-43-2Relevant academic research and scientific papers
Design and synthesis of novel platelet fibrinogen receptor antagonists with 2H-1,4-benzoxazine-3(4H)-one scaffold. A systematic study
Anderluh, Marko,Cesar, Jǒko,?tefanǐ, Petra,Kikelj, Danijel,Janě, Damjan,Murn, Jernej,Nadrah, Kristina,Tominc, Mojca,Addicks, Elisabeth,Giannis, Athanassios,Stegnar, Mojca,Dolenc, Marija Sollner
, p. 25 - 49 (2007/10/03)
New platelet glycoprotein IIb/IIIa (GP IIb/IIIa, integrin αIIbβ3) antagonists were prepared on a 2H-1,4-benzoxazine-3(4H)-one scaffold. Their anti-aggregatory activities in human platelet rich plasma and their affinity towards α sub
Conformationally tailored N-[(2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)carbonyl]proline templates as molecular tools for the design of peptidomimetics. Design and synthesis of fibrinogen receptor antagonists.
Stefanic, Petra,Simoncic, Zvone,Breznik, Matej,Plavec, Janez,Anderluh, Marko,Addicks, Elisabeth,Giannis, Athanassios,Kikelj, Danijel
, p. 1511 - 1517 (2007/10/03)
The proline peptide bond was shown by 2D proton NMR studies to exist exclusively in the trans conformation in benzyl (2S)-1-[[(2S)-2-methyl-6-nitro-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl]carbonyl]-2-pyrrolidinecarboxylate [(S,S)-11], benzyl (2S)-1-[[(2S
