154374-84-2

Upstream product

• 615-43-0 2-iodophenylamine 
• 116491-50-0 2-(hex-1-ynyl)aniline 
• 76-05-1 trifluoroacetic acid 
• 693-02-7 hex-1-yne 

Relevant academic research and scientific papers

Synthesis of fluorine-containing multisubstituted phenanthridines by rhodium-catalyzed alkyne [2+2+2] cycloaddition and tandem sp2 C-H difluoromethylenation

A highly efficient method for the synthesis of fluorine-containing multisubstituted phenanthridines through Rh-catalyzed alkyne [2+2+2] cycloaddition reactions has been developed. This method exhibits excellent functional-group compatibility. When a bromodifluoromethyl group, rather than a trifluoromethyl group, was employed in the cycloaddition reaction, more-complicated polycyclic compounds were obtained through tandem Rh-catalyzed cycloaddition/C-H difluoromethylenation. This route provides convenient access to fluorine-containing polycyclic compounds. [2+2+2] Little boys: Fluorine-containing multisubstituted phenanthridines have been synthesized through Rh-catalyzed alkyne [2+2+2] cycloaddition reactions (see scheme; FG=functional group). Polycyclic compounds were also obtained through Rh-catalyzed C-H difluoromethylenation. Copyright

Intramolecular activation of imidate with cationic gold(I) catalyst: A new benzylation reaction of alcohols

Benzylation of alcohols with benzyl (Z)-2,2,2-trifluoro-N-(2-alkynylphenyl)acetimidates 5a-f in the presence of a cationic gold(I) catalyst was investigated. Reagent 5f was the most effective, affording benzyl ethers in good yields. Our results indicate that these gold(I)-activated imidates are effective leaving groups.

2,3-disubstituted indole derivative and preparation method thereof

Provided is a 2,3-disubstituted indole derivative. The 2,3-disubstituted indole derivative has great biological activity and can be widely applied to light chemical industry, agriculture, medicine andother fields. Additionally, the invention also relates