154379-07-4Relevant academic research and scientific papers
Administration of TLR7 ligands and prodrugs thereof for treatment of infection by hepatitis C virus
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Page/Page column 41, (2008/06/13)
This invention relates to methods for treating or preventing hepatitis C virus infections in mammals using Toll-Like Receptor (TLR)7 ligands and prodrugs thereof. More particularly, this invention relates to methods of orally administering a therapeutically effective amount of one or more prodrugs of TLR7 ligands for the treatment or prevention of hepatitis C viral infection. Oral administration of these TLR7 immunomodulating ligands and prodrugs thereof to a mammal provides therapeutically effective amounts and reduced undesirable side effects.
Pyrimidines. 24. Analogues and derivatives of 2-amino-5-bromo-6-phenyl- 4(3H)-pyrimidinone (ABPP)
Fan,Cheng
, p. 1273 - 1276 (2007/10/02)
Preparation of a number of derivatives of 2-amino-5-bromo-6-phenyl-4(3H)- pyrimidinone (ABPP) including the 2-dialkylaminoalkylamino-, 2- hydroxyalkylamino-, 2-ethoxycarbonylamino- and 2-alkylaminocarbonyl-amino- groups substituted on the pyrimidine ring as well as preparation of 1- (alkylaminoalkyl)-4,6-dioxo-8-phenyl-2,3,4,6-tetrahydro-1H-pyrimido[1,2- a]pyrimidines and 3,5-dioxo-7-phenyl-1,2,3,5-tetrahydroimidazo[1,2- a]pyrimidines with or without the bromo-substitution are reported.
