154391-68-1Relevant academic research and scientific papers
Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors
Beck, Hilary P.,Degraffenreid, Michael,Fox, Brian,Allen, John G.,Rew, Yosup,Schneider, Stephen,Saiki, Anne Y.,Yu, Dongyin,Oliner, Jonathan D.,Salyers, Kevin,Ye, Qiuping,Olson, Steven
, p. 2752 - 2755 (2011)
Human murine double minute 2 (MDM2) is a negative regulator of p53, which plays an important role in cell cycle and apoptosis. We report several optimizations to the synthesis of the chromenotriazolopyrimidine series of MDM2-p53 protein-protein interaction inhibitors. Additionally, the in vitro and in vivo stability, pharmacokinetic properties and solubility were improved through N-substitution.
