Bioorganic and Medicinal Chemistry Letters p. 2752 - 2755 (2011)
Update date:2022-08-02
Topics:
Beck, Hilary P.
Degraffenreid, Michael
Fox, Brian
Allen, John G.
Rew, Yosup
Schneider, Stephen
Saiki, Anne Y.
Yu, Dongyin
Oliner, Jonathan D.
Salyers, Kevin
Ye, Qiuping
Olson, Steven
Human murine double minute 2 (MDM2) is a negative regulator of p53, which plays an important role in cell cycle and apoptosis. We report several optimizations to the synthesis of the chromenotriazolopyrimidine series of MDM2-p53 protein-protein interaction inhibitors. Additionally, the in vitro and in vivo stability, pharmacokinetic properties and solubility were improved through N-substitution.
View MoreSynchem Pharma Co.,Ltd(expird)
Contact:+0086-21-61984905-1
Address:Building 60,Zimian Park, LongYang industrial Area, 1515Nong,Yuandong Road Fengxian District, Shanghai ,China
Cerametek Materials(ShenZhen)Co., Ltd.
Contact:+86-755-2324.2554
Address:A3-#9, YongChuan Street, Suite 501
Chongqing Changfeng Chemical Co., Ltd.
website:http://www.changfengchem.com
Contact:+86-23-67896333
Address:30th Floor, Longhu Ziduxingzuo Building A, 1st Branch,YuSong Rd., Yubei District, Chongqing, China
Yuan Shi(SuQian)Biotechnology Co.,Ltd
website:http://www.yuanshibio.com
Contact:+86-527-84226672
Address:jiangsu suqian
Contact:
Address:No.89,Xinhua Road, Langfang City,Hebei China
Doi:10.1021/ol403741m
(2014)Doi:10.1248/cpb.41.1933
(1993)Doi:10.1016/S0040-4039(00)61395-3
(1993)Doi:10.1002/recl.19931121005
(1993)Doi:10.1016/j.tetlet.2005.08.068
(2005)Doi:10.1021/om401018f
(2014)