154422-50-1Relevant articles and documents
N-Benzylindole-2-carboxylic acids: Potent functional antagonists of the CCR2b chemokine receptor
Kettle, Jason G.,Faull, Alan W.,Barker, Andy J.,Davies, D. Huw,Stone, Michael A.
, p. 405 - 408 (2007/10/03)
Screening of the corporate database led to the discovery of a novel series of N-benzylindole-2-carboxylic acid CCR2b chemokine receptor antagonists. These compounds demonstrate high affinity and functional inhibition of the CCR2b receptor. A discussion of
Fischer indolization of variously ortho-substituted phenylhydrazones (Fischer indolization and its related compounds. XXV)
Murakami,Watanabe,Yokoyama,Naomachi,Iwase,Watanabe,Morihata,Okuyama,Kamakura,Takahashi,Atoda,Tojo,Morita,Ishii
, p. 1910 - 1919 (2007/10/02)
Various kinds of ethyl pyruvate 2-(2-substituted phenyl)hydrazones (1) were subjected to Fischer indolization with acid catalysts. All the phenylhydrazones gave corresponding normal 7-substituted indoles (2). In addition, phenylhydrazones whose ortho-substituent is electron-donative or has a central atom with an unshared electron pair tended to give the 4- or 5- substituted indole (3), which was produced by migration of the ortho- substituent during cyclization, whereas those whose ortho-substituent is electron-attractive tended to give little or no such abnormal product. The kind of acid catalyst used had some effect on the yield ratio of products but not on the kind of products.
