1544273-95-1

Basic information

• Product Name: 5-(4-methoxyphenyl)-1,3-dimethyl-6-phenyl-7-thioxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
• Synonyms: 5-(4-methoxyphenyl)-1,3-dimethyl-6-phenyl-7-thioxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
• CAS NO: 1544273-95-1
• Molecular Weight: 408.481
• Mol File: 1544273-95-1.mol

Chemical Properties

• CAS DataBase Reference: 5-(4-methoxyphenyl)-1,3-dimethyl-6-phenyl-7-thioxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-methoxyphenyl)-1,3-dimethyl-6-phenyl-7-thioxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione(1544273-95-1)
• EPA Substance Registry System: 5-(4-methoxyphenyl)-1,3-dimethyl-6-phenyl-7-thioxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione(1544273-95-1)

Safety Data

• Hazardous Substances Data: 1544273-95-1(Hazardous Substances Data)

Upstream product

• 6642-31-5 6-Amino-1,3-dimethylbarbituric acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 103-72-0 phenyl isothiocyanate 

Relevant articles and documents

Green synthesis of new pyrimido[4,5-d]pyrimidine derivatives using 7-aminonaphthalene-1,3-disulfonic acid-functionalized magnetic Fe3O4@SiO2 nanoparticles as catalyst

We, herein, describe a novel, simple, efficient and one-pot multi-component procedure for the synthesis of substituted pyrimido[4,5-d]pyrimidines via reaction of N,N-dimethyl-6-amino uracil, isothiocyanate and aromatic aldehydes promoted by 7-aminonaphthalene-1,3-disulfonic acid (ANDSA)-functionalized magnetic Fe3O4@SiO2 in water as solvent and without using any other harmful organic reagents. Compared with other reactions, using these organic–inorganic hybrid heterogeneous catalysts can help us to achieve a green procedure, high catalytic activity, easy recovery with an external magnetic field, and short reaction times.

MIL-53(Fe): Introduction of a new catalyst for the synthesis of Pyrimido[4,5-d]pyrimidine derivatives under solvent-free conditions

In this study, the efficiency of MIL-53(Fe) metal-organic framework (MOF) the one-pot, three-component reaction of isothiocyanate, aromatic aldehydes and 6-aminouracil and/or N,N-dimethyl-6-aminouracil to form pyrimido[4,5-d]pyrimidine derivatives is inve

An efficient one-pot three-component synthesis of pyrimido[4,5-d]pyrimidine derivatives in aqueous medium

[Figure not available: see fulltext.] A fast, efficient, and green synthesis of pyrimido[4,5-d]pyrimidine derivatives has been achieved via one-pot three-component reaction starting from 6-amino-N,N-dimethyluracil, phenylisothiocyanate or phenylisocyanate

An efficient and regioselective one-pot multi-component synthesis of pyrimido[4,5-d]pyrimidine derivatives in water

Pyrimido[4,5-d]pyrimidine derivatives 4 have been prepared in an efficient and regioselective manner in water via multi-component reaction of isothiocyanate 1, aromatic aldehyde 2, N,N-dimethyl-6-amino uracil 3 in the presence of p-toluenesulfonic acid (p-TSA) as a Lewis acid catalyst.