154463-67-9Relevant academic research and scientific papers
New unnatural L-nucleoside enantiomers: From their stereospecific synthesis to their biological activities
Gosselin,Boudou,Griffon,Pavia,Pierra,Imbach,Aubertin,Schinazi,Faraj,Sommadossi
, p. 1389 - 1398 (2007/10/03)
Several purine and pyrimidine β-L-dideoxynucleosides were stereospecifically synthesized and their antiviral properties examined. Two of them, namely β-L-2',3'-dideoxyadenosine (β-L-ddA) and its 2',3'- didehydro derivative (β-L-d4A) were found to have significant anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HSV) activities in cell culture.
Synthesis and antiviral evaluation of β-L-xylo-furanosyl nucleosides of the five naturally occurring nucleic acid bases
Gosselin,Bergogne,Imbach
, p. 1229 - 1233 (2007/10/02)
The β-L-xylo-furanosyl analogues of the naturally occurring nucleosides have been synthesized and their antiviral properties examined. All these compounds were hitherto unknown and they were stereospecifically prepared by glycosylation of pyrimidine and p
