154470-22-1Relevant academic research and scientific papers
Synthesis and characterization of pyruvate-isoniazid analogs and their copper complexes as potential ICL inhibitors
Shingnapurkar, Dipti,Dandawate, Prasad,Anson, Christopher E.,Powell, Annie K.,Afrasiabi, Zahra,Sinn, Ekkehard,Pandit, Shital,Venkateswara Swamy,Franzblau, Scott,Padhye, Subhash
, p. 3172 - 3176 (2012)
Currently used anti-tubercular drugs target actively growing Mycobacterium tuberculosis (Mtb) but there are no current therapies targeting persistent mycobacteria. Isocitrate lyase (ICL) is an important enzyme of the glyoxylate shunt pathway used by Mtb f
