154479-61-5

Upstream product

• 459-46-1 4-Fluorobenzyl bromide 
• 675-20-7 piperidin-2-one 
• 352-11-4 1-chloromethyl-4-fluorobenzene 

Downstream Products

• 865088-39-7 1-(4-fluorobenzyl)-3-(phenylsulfinyl)piperidin-2-one 
• 865088-61-5 4-{1-[(cyclopropylmethyl)amino]-1-methylethyl}-1-(4-fluorobenzyl)piperidin-2-one 
• 865088-62-6 ethyl ((cyclopropylmethyl){1-[1-(4-fluorobenzyl)-2-oxopiperidin-4-yl]-1-methylethyl}amino)(oxo)acetate 
• 865088-20-6 6-(cyclopropylmethyl)-2-(4-fluorobenzyl)-8-hydroxy-5,5-dimethyl-2,3,4,4a,5,6-hexahydro-2,6-naphthyridine-1,7-dione 
• 865088-63-7 2-(4-fluorobenzyl)-8-hydroxy-6-methyl-2,3,4,4a,5,6-hexahydro-2,6-naphthyridine-1,7-dione-5-carboxylic acid 
• 865088-46-6 Ethyl ({1-[1-(4-fluorobenzyl)-2-oxopiperidin-4-yl]-1-methylethyl}amino)(oxo)acetate 
• 865088-06-8 2-(4-fluorobenzyl)-8-hydroxy-5,5,6-trimethyl-2,3,4,4a,5,6-hexahydro-2,6-naphthyridine-1,7-dione 
• 865088-05-7 2-(4-fluorobenzyl)-8-hydroxy-6-methyl-2,3,4,4a,5,6-hexahydro-2,6-naphthyridine-1,7-dione 
• 865088-57-9 1-(4-fluorobenzyl)-4-(1-nitropropyl)piperidin-2-one 
• 865088-44-4 1-(4-fluorobenzyl)-4-(1-methyl-1-nitroethyl)piperidin-2-one 
• 865088-45-5 4-(1-amino-1-methylethyl)-1-(4-fluorobenzyl)piperidine-2-one 
• 865088-58-0 4-(1-aminopropyl)-1-(4-fluorobenzyl)piperidin-2-one 

Relevant academic research and scientific papers

N-oxidation - An intermediary step occurring during biotransformation of cycloalkylamines with subsequent formation of their 2-oxo-derivatives

Drugs being N-substituted secondary cycloalkylamines, e.g. derivatives of pyrrolidine and piperidine, are often metabolized to the corresponding 2-oxo-derivatives (lactames). The accepted mechanism of this reaction may be postulated as follows: 1) formati

Hiv Integrase Inhibitors

Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein Z, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

HIV INTEGRASE INHIBITORS

Hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula (I) are inhibitors of HIV integrase and inhibitors of HIV replication wherein X1, X2, R4 and R5 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.