N-oxidation - An intermediary step occurring during biotransformation of cycloalkylamines with subsequent formation of their 2-oxo-derivatives

Article abstract of DOI:10.1002/ardp.19923250110

Drugs being N-substituted secondary cycloalkylamines, e.g. derivatives of pyrrolidine and piperidine, are often metabolized to the corresponding 2-oxo-derivatives (lactames). The accepted mechanism of this reaction may be postulated as follows: 1) formati