1545-96-6

Basic information

• Product Name: Benzenesulfonamide, N-(4-fluorophenyl)-4-nitro-
• CAS NO: 1545-96-6
• Molecular Formula: C12H9FN2O4S
• Molecular Weight: 296.279
• Mol File: 1545-96-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-(4-fluorophenyl)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-(4-fluorophenyl)-4-nitro-(1545-96-6)
• EPA Substance Registry System: Benzenesulfonamide, N-(4-fluorophenyl)-4-nitro-(1545-96-6)

Safety Data

• Hazardous Substances Data: 1545-96-6(Hazardous Substances Data)

Upstream product

• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 349470-56-0 N-(4-fluorophenyl)-4-(phenylureido)benzene sulphonamide 
• 925459-60-5 4'-fluoro-N-methyl-4-nitrobenzenesulfonanilide 
• 1494-85-5 4-amino-N-(4-fluorophenyl)benzene-1-sulfonamide 

Relevant articles and documents

Oxidative fluorination of N-arylsulfonamides

We report a late stage oxidative nucleophilic fluorination of N-arylsulfonamides, a class of compounds so far not considered as precursors to 4-fluorophenyl sulfonamides. By installing a para-positioned tert-butyl substituent on the aniline, oxidative fluorination takes place regioselectively in the presence of HF·pyridine and PIDA. This methodology has been shown to give good yields for a variety of ortho- and meta-functionalised N-arylsulfonamides and has been adapted for radiofluorination to give 4-[18F]fluorophenyl sulfonamides under carrier added conditions.