154502-82-6

Basic information

• Product Name: 1-(3,4-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-3H-isochromen-3-one
• Synonyms: 1-(3,4-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-3H-isochromen-3-one
• CAS NO: 154502-82-6
• Molecular Formula: C19H20O6
• Molecular Weight: 344.3585
• Mol File: 154502-82-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(3,4-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-3H-isochromen-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-3H-isochromen-3-one(154502-82-6)
• EPA Substance Registry System: 1-(3,4-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-3H-isochromen-3-one(154502-82-6)

Safety Data

• Hazardous Substances Data: 154502-82-6(Hazardous Substances Data)

Upstream product

• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 154502-76-8 diethyl 2-<2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl>propanedioate 
• 52806-37-8 (4,5-dimethoxy-2-methylphenyl)(3,4-dimethoxyphenyl)methanone 
• 154502-77-9 2-<2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl>acetic acid 

Relevant articles and documents

Bsi(OTf)3-mediated tandem annulation of 1-aryl isochroman-3-ones with oxygenated arenes: One-pot synthesis of polyoxygenated homotriptycenes

Bi(OTf)3 (bismuth triflate)-mediated one-pot tandem annulation of oxygenated 1-aryl isochroman-3-ones with oxygenated arenes provides polyoxygenated homotriptycenes in moderate to good yields in MeNO2 at reflux (101 °C) for 10 h under an air atmosphere and easy-operational conditions via intermolecular and intramolecular Friedel-Crafts type procedures. A plausible mechanism is proposed and discussed. This protocol provides a highly effective ring-closure via three carbon-carbon (C-C) bond formations.

Trifluoroacetic Anhydride Mediated One-Pot Synthesis of 1-Aryl Isochroman-3-ones via the Carboxy-Pictet-Spengler Reaction

In this paper, a novel and open-vessel route for the facile-operational synthesis of 1-aryl isochroman-3-ones is described via (CF3CO)2O (trifluoroacetic anhydride, TFAA)-mediated intermolecular (4 + 2) annulation of oxygenated arylacetic acids with arylaldehydes or ketones under mild reaction conditions. A plausible mechanism is proposed and discussed herein. Various reaction conditions are investigated for efficient transformation under an environmentally friendly one-pot carboxy-Pictet-Spengler reaction.

A new synthesis of 3-isochromanone derivatives based on the reaction of o-acylbenzyllithiums with ethyl chloroformate

A new method for the preparation of 3-isochromanone derivatives is reported. The method consists of the ethoxycarbonylation of o-acylbenzyllithiums with ethyl chloroformate and the subsequent NaBH4 reduction of the resulting o-acylphenylacetic