154558-56-2Relevant academic research and scientific papers
A SIMPLE METHOD FOR THE DIRECT BIS-ACYLATION THE PRIMARY AMINO GROUPS IN SPERMIDINE AND OTHER LINEAR TRIAMINES
Joshua, Alummoottil V.,Scott, John R.
, p. 5725 - 5728 (1984)
A simple and efficient method for the direct symmetrical bis-acylation of spermidine and other linear triamines using acylimidazoles is described.By this procedure, the siderophore natural product N1,N8-bis(2,3-dihydroxybenzoyl) spermidine was synthesized in an overall yield of 70percent in two steps.
An Environmentally Sustainable Mechanochemical Route to Hydroxamic Acid Derivatives
Mocci, Rita,De Luca, Lidia,Delogu, Francesco,Porcheddu, Andrea
supporting information, p. 3135 - 3144 (2016/10/09)
An operationally simple, and cost efficient conversion of carboxylic acids into hydroxamic acid derivatives via a high-energy mechanochemical activation is presented. This ball milling methodology was applied to a wide variety of carboxylic acids dramatically improving purification issues associated with this class of molecules, which still remain one of the main bottlenecks of classical methodologies. (Figure presented.).
Synthesis and SAR evaluation of 1,2,4-triazoles as A2A receptor antagonists
Alanine, Alexander,Anselm, Lilli,Steward, Lucinda,Thomi, Stefan,Vifian, Walter,Groaning, Michael D.
, p. 817 - 821 (2007/10/03)
The synthesis and in vitro structure-activity relationships (SAR) of a series of triazoles as A2A receptor antagonists is reported. This resulted in the identification of potent, selective and permeable 1,2,4-triazoles such as 42 for further op
N-Sulfonyloxy-β-lactam inhibitors for β-lactamases
Bulychev, Alexey,Bellettini, John R.,O'Brien, Michael,Crocker, Peter J.,Samama, Jean-Pierre,Miller, Marvin J.,Mobashery, Shahriar
, p. 5719 - 5728 (2007/10/03)
Structure-function analysis with a series of N-sulfonyloxy β-lactam molecules as inhibitors of β-lactamases is reported. The best of these compounds acylate the active site of the class A TEM-1 β-lactamase from Escherichia coli rapidly, and resist deacylation. Whereas acylation of the active site of the class C β-lactamase from Enterobacter cloacae was not seen, these compounds function as competitive inhibitors of this enzyme. (C) 2000 Elsevier Science Ltd.
Synthesis of the smallest tris-(catecholamide) siderophore analogue
Cheraiti,Brik,Kunesch,Gaudemer
, p. 149 - 152 (2007/10/03)
The tris-(catecholamide) (H6L) (8) was synthesised in six steps and characterized. This is the smallest analogue of naturally occurring siderophores structurally related to an approved enterobactin and protochelin model, known up to now.
