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Usage

Uses

Used in Medicinal Chemistry:
L-2-(4-BROMOTHIENYL)ALANINE is used as a building block for the development of new pharmaceuticals and biologically active molecules, owing to its unique structure and properties that can be harnessed in drug design and synthesis.
Used in Drug Development:
L-2-(4-BROMOTHIENYL)ALANINE is utilized as a key component in the creation of innovative drugs, potentially leading to advancements in treating various medical conditions by leveraging its distinct chemical features.
Used in Protein Structure Research:
L-2-(4-BROMOTHIENYL)ALANINE is employed as a research tool for scientists studying protein structures, helping to understand the implications of its unique molecular composition on protein function and stability.
Used in Nutrition and Health Supplements:
L-2-(4-BROMOTHIENYL)ALANINE is used as an ingredient in health supplements, potentially contributing to the development of products that support overall health and well-being, given its association with the essential amino acid, alanine.

Upstream product

• 103686-16-4 trans-3-(4-bromothiophen-2-yl)propenoic acid 
• 18791-75-8 4-Bromothiophen-2-aldehyde 

Relevant academic research and scientific papers

Synthesis of Enantiomerically Pure Ring-Substituted l -Pyridylalanines by Biocatalytic Hydroamination

Current routes to nitrogen-containing heteroarylalanines involve complex multistep synthesis and are often reliant on protection/deprotection steps and wasteful chromatographic purifications. In order to complement existing methodologies, a convenient telescopic strategy was developed for the synthesis of l-pyridylalanine analogues (12 examples) and other l-heteroarylalanines (5 examples) starting from the corresponding aldehydes. A phenylalanine ammonia lyase (PAL) from Anabaena variabilis was used as the biocatalyst to give conversions ranging between 88 and 95%, isolated yields of 32-60%, and perfect enantiopurity (>99% ee) by employing an additional deracemization cascade where necessary.

Asymmetric synthesis of L-thienylalanines

L-Thienylalanines were prepared via the hydantoin and azlactone routes with the key step consisting of the microbial transamination of 2-hydroxy-3-thienylacrylic with L-aspartic acid as amino donor.The transamination reaction was performed by a genetically engineered E. coli strain on scales up to 100 g of L-3-(2-thienyl)alanine 1a and is also applicable to the preparation of the isomeric amino acid 1b and some ring-substituted derivatives.