154596-79-9Relevant academic research and scientific papers
Structure-based design of an inhibitor of the zinc peptidase thermolysin
Morgan, Bradley P.,Holland, Debra R.,Matthews, Brian W.,Bartlett, Paul A.
, p. 3251 - 3260 (1994)
The full cycle of design, synthesis, and enzymatic and crystallographic evaluation of a structure-based inhibitor of thermolysin is described. Using the structure of the complex of thermolysin with Cbz-Gly(P)-Leu-Leu (K(i) = 9 nM; 'Gly(P)' = NHCH2/s
