Journal of the American Chemical Society p. 3251 - 3260 (1994)
Update date:2022-08-04
Topics: Spectrophotometry Ligand Molecular docking IC50 binding affinity HPLC (high-performance liquid chromatography) X-ray crystallography Chelation Inhibitor Circular Dichroism (CD) Structure-Activity Relationship (SAR) Enzyme Kinetics Substrate Site-Directed Mutagenesis Catalytic Mechanism Peptide bond Active site Assay Structure-based design Mutagenesis Isothermal titration calorimetry (ITC)
Morgan, Bradley P.
Holland, Debra R.
Matthews, Brian W.
Bartlett, Paul A.
The full cycle of design, synthesis, and enzymatic and crystallographic evaluation of a structure-based inhibitor of thermolysin is described. Using the structure of the complex of thermolysin with Cbz-Gly(P)-Leu-Leu (K(i) = 9 nM; 'Gly(P)' = NHCH2 View More
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Doi:10.1016/S0957-4166(00)80404-8
(1994)Doi:10.1039/c7gc03514d
(2018)Doi:10.1021/ja00101a011
(1994)Doi:10.1016/S0040-4020(01)81549-0
(1993)Doi:10.1016/j.bmcl.2013.12.095
(2014)Doi:10.1016/S0040-4039(00)93372-0
(1993)
