Journal of the American Chemical Society p. 3251 - 3260 (1994)
Update date:2022-08-04
Topics: Spectrophotometry Ligand Molecular docking IC50 binding affinity HPLC (high-performance liquid chromatography) X-ray crystallography Chelation Inhibitor Circular Dichroism (CD) Structure-Activity Relationship (SAR) Enzyme Kinetics Substrate Site-Directed Mutagenesis Catalytic Mechanism Peptide bond Active site Assay Structure-based design Mutagenesis Isothermal titration calorimetry (ITC)
Morgan, Bradley P.
Holland, Debra R.
Matthews, Brian W.
Bartlett, Paul A.
The full cycle of design, synthesis, and enzymatic and crystallographic evaluation of a structure-based inhibitor of thermolysin is described. Using the structure of the complex of thermolysin with Cbz-Gly(P)-Leu-Leu (K(i) = 9 nM; 'Gly(P)' = NHCH2 View More
Linyi Shengxin Pharmaceutical R&D Co., Ltd
Contact:+86-18653953873
Address:West First of Yufeng Road, Yishui County
Contact:+86-13914766747
Address:Floors 21&22, Jin Cheng Tower, No. 216 Middle Longpan Road, Nanjing
ShangHai Original Economy-Trade Develop Co.,Ltd.,
Contact:86-21-68552131
Address:shanghai
Xi'an Tizan Tech & Industry Co., Ltd.
Contact:86-18629066522
Address:C3009 TANG FENG INTERNATIONAL PLAZA, NO.18 FENGHUI NAN ROAD, XI'AN HIGH TECH ZONE, 710075 CHINA.
Chengdu Gelipu Biotechnology Co., Ltd.
website:http://www.glp-china.com
Contact:86-28-82610909
Address:chegndu
Doi:10.1016/S0957-4166(00)80404-8
(1994)Doi:10.1039/c7gc03514d
(2018)Doi:10.1021/ja00101a011
(1994)Doi:10.1016/S0040-4020(01)81549-0
(1993)Doi:10.1016/j.bmcl.2013.12.095
(2014)Doi:10.1016/S0040-4039(00)93372-0
(1993)
