Journal of the American Chemical Society p. 3251 - 3260 (1994)
Update date:2022-08-04
Topics: Spectrophotometry Ligand Molecular docking IC50 binding affinity HPLC (high-performance liquid chromatography) X-ray crystallography Chelation Inhibitor Circular Dichroism (CD) Structure-Activity Relationship (SAR) Enzyme Kinetics Substrate Site-Directed Mutagenesis Catalytic Mechanism Peptide bond Active site Assay Structure-based design Mutagenesis Isothermal titration calorimetry (ITC)
Morgan, Bradley P.
Holland, Debra R.
Matthews, Brian W.
Bartlett, Paul A.
The full cycle of design, synthesis, and enzymatic and crystallographic evaluation of a structure-based inhibitor of thermolysin is described. Using the structure of the complex of thermolysin with Cbz-Gly(P)-Leu-Leu (K(i) = 9 nM; 'Gly(P)' = NHCH2 View More
hangzhou sunchem trading co., ltd.
Contact:13588470430--
Address:Room 406-407, the 4th Building, No549
Contact:86+21-56421993
Address:3F,BUILDING 10,NO.2889 JINKE ROAD, SHANGHAI.
Nantong Kaixin Pharma Chemical Co.,Ltd.
Contact:86-513-85250786
Address:2-1103 Huachen Mansion, 111 Gongnong Road,Nantong, Jiangsu, China
Winchem Industrial Co. Ltd.(expird)
Contact:86-574-83851061 86-574-87083208
Address:Room 905, No.3 Building,East Business Center, 456 Xingning Road, Ningbo City,China
Contact:+86-574- 87178138; 87297407
Address:No. 809, Liudingxingzuo, cangsong road, Ningbo, China
Doi:10.1016/S0957-4166(00)80404-8
(1994)Doi:10.1039/c7gc03514d
(2018)Doi:10.1021/ja00101a011
(1994)Doi:10.1016/S0040-4020(01)81549-0
(1993)Doi:10.1016/j.bmcl.2013.12.095
(2014)Doi:10.1016/S0040-4039(00)93372-0
(1993)
