154650-79-0

Basic information

• Product Name: 3-fluoro-2-(trimethylsilyl)benzonitrile
• Synonyms: 3-fluoro-2-(trimethylsilyl)benzonitrile
• CAS NO: 154650-79-0
• Molecular Weight: 193.296
• Mol File: 154650-79-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-fluoro-2-(trimethylsilyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-2-(trimethylsilyl)benzonitrile(154650-79-0)
• EPA Substance Registry System: 3-fluoro-2-(trimethylsilyl)benzonitrile(154650-79-0)

Safety Data

• Hazardous Substances Data: 154650-79-0(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 403-54-3 m-Fluorobenzonitrile 

Downstream Products

• 473415-88-2 3-Fluoro-4-[(3-fluorophenyl)(hydroxy)methyl]-2-(1,1,1-trimethylsilyl)benzonitrile 

Relevant articles and documents

Facile Synthesis of 2-Bromo-3-fluorobenzonitrile: An Application and Study of the Halodeboronation of Aryl Boronic Acids

A scaleable synthesis of 2-bromo-3-fluorobenzonitrile via the NaOMe-catalyzed bromodeboronation of 2-cyano-6-fluorophenylboronic acid was developed. The generality of this transformation was demonstrated through the halodeboronation of a series of aryl boronic acids. Both aryl bromides and aryl chlorides were formed in good to excellent yields when the corresponding aryl boronic acid was treated with 1,3-dihalo-5,5-dimethylhydantoin and 5 mol % NaOMe.

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