154656-94-7Relevant academic research and scientific papers
CARBOXAMIDE DERIVATIVE
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Page/Page column 74, (2010/11/08)
An SGLT inhibitor comprising a compound of the formula: (|) wherein the ring A is an optionally substituted ring; R1 is an optionally substituted hydrocarbon group, etc.; each of R2 and R3 independently is a hydrogen atom, an optionally substituted hydrocarbon group, etc.; R4 is an optionally substituted hydrocarbon group, etc.; and X is a bivalent chain group whose main chain consists of 1 to 6 atoms. This SGLT inhibitor is useful as a preventive/therapeutic agent for diabetes mellitus, obesity, hypertension, hyperlipemia, etc.
Synthesis and biological properties of new 1β-methylcarbapenems
Shin, Kye Jung,Yoo, Kyung Ho,Kim, Dong Jin,Park, Sang Woo,Ko, Bong Suck,Lee, Sang Joo,Huh, Jae Doo,Park, Seung Yong
, p. 1607 - 1612 (2007/10/03)
The synthesis and biological activity of the novel series of 1β- methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R2=NH2) showed an excellent and a broad spectrum as well as high renal DHP- I stability. It also possessed good in vivo efficacy and high safety.
