1547236-50-9Relevant academic research and scientific papers
A copper-catalyzed domino route toward purine-fused tricyclic derivatives
Xie, Ming-Sheng,Chu, Zhi-Liang,Niu, Hong-Ying,Qu, Gui-Rong,Guo, Hai-Ming
, p. 1093 - 1099 (2014/03/21)
Purine-fused tricyclic derivatives have been synthesized via a copper-catalyzed domino Michael/oxidative cross-coupling reaction between adenines and nitroolefins for the first time. With air as the oxidant, this method has high regioselectivity, which provides a new route for constructing purine-nucleoside-conjugated systems with two newly formed C-N bonds. Meanwhile, purine nucleosides with an exocyclic amino group could be obtained easily by simple reduction, which may lead to potential applications in fluorescence recognition of various bases in vivo.
