154726-22-4Relevant academic research and scientific papers
Preparation and characterization of magnetically separable MgFe2O4/Mg(OH)2 nanocomposite as an efficient heterogeneous catalyst for regioselective one-pot synthesis of β-chloroacetates from epoxides
Hassanzadeh, Shadi,Eisavi, Ronak,Abbasian, Mojtaba
, (2018)
Magnetically separable MgFe2O4/Mg(OH)2 nanoparticles were fabricated and characterized using various techniques. These nanoparticles were used as a new catalyst for regioselective one-pot synthesis of β-chloroacetates from epoxides in the presence of NiCl2?6H2O and acetic anhydride. All reactions were carried out in ethanol at room temperature within 22–80?min giving the β-chloroacetates in high to excellent yields. The nanocatalyst was easily separated using an external magnet and reused several times without any significant loss of efficiency or magnetic property.
Enzymatic preparation of (1S,2R)- and (1R,2S)-stereoisomers of 2-halocycloalkanols
Kolodiazhna, Olga O.,Kolodiazhna, Anastasy O.,Kolodiazhnyi, Oleg I.
, p. 37 - 42 (2013/02/25)
The stereoisomers of cis-2-halocycloalkanols were resolved by a kinetically controlled transesterification with vinyl acetate in the presence of lipases in organic media. High enantioselectivities (ee >98%) and good isolated yields were obtained for all substrates using the appropriate lipase. Burkholderia cepacia lipase was the most efficient enzyme for the resolution of these substrates. The enantiomeric purities of the compounds were defined by derivatization with Mosher's acid and the absolute configurations were determined by chemical correlation.
Synthesis of an enantiomerically pure aminoisoquinocarbazole with antiarrhythmic activity via lipase-catalyzed enantioselective transesterification
Fukazawa, Tetuya,Shimoji, Yasuo,Hashimoto, Toshihiko
, p. 1649 - 1658 (2007/10/03)
Enantiomerically pure (R)-2-cyclohexen-1-ol 5 was prepared via lipase- catalyzed enantioselective transesterification of 2-substituted cyclohexanol, and stereospecifically converted to (-)-(2-cyclohexenyl)acetic acid 4. Enantiomerically pure aminoisoquinocarbazole 1 (RS-2135) was synthesized stereoselectively from 4, using an intramolecular Diels-Alder reaction and Curtius rearrangement.
Synthesis of enantiomerically pure (R)-2-cycloalken-1-ols using highly enantioselective enzymatic transesterification
Fukazawa,Hashimoto
, p. 2323 - 2326 (2007/10/02)
Optically pure (R)-2-cycloalken-1-ols were synthesized via highly enantioselective lipase-catalyzed transesterification of 2-substituted cycloalkanols.
