1547432-48-3

Upstream product

• 23652-91-7 (Z)-1-methyl-1-(N-acetyl)amino-2-acetylethylene 
• 375-72-4 Nonafluorobutanesulfonyl fluoride 
• 1547432-74-5 (Z)-N-(4-oxopent-2-en-2-yl)-3-phenylpropanamide 
• 501-52-0 3-Phenylpropionic acid 
• 123-54-6 acetylacetone 
• 1118-66-7 4-Aminopent-3-en-2-one 
• 645-45-4 hydrocinnamic acid chloride 

Relevant academic research and scientific papers

Trimethylsilyl trifluoromethanesulfonate-promoted cyclocondensation of β-ketoenamides and subsequent nonaflation to pyrid-2-yl and pyrid-4-yl nonaflates as flexible precursors for polysubstituted pyridines

The intramolecular condensation of β-ketoenamides to 2- and/or 4-pyridone derivatives using either KOt-Bu or trimethylsilyl trifluoromethanesulfonate/Hu?nig's base was investigated. Subsequent nonaflation of the cyclization products allowed a facile purification and further functionalization through Suzuki-Miyaura couplings leading to new highly substituted pyridine derivatives. The dependence of the regioselectivity of cyclocondensation on the structure of the β-ketoenamides is discussed. Georg Thieme Verlag Stuttgart New York.