1547432-74-5Relevant academic research and scientific papers
Trimethylsilyl trifluoromethanesulfonate-promoted cyclocondensation of β-ketoenamides and subsequent nonaflation to pyrid-2-yl and pyrid-4-yl nonaflates as flexible precursors for polysubstituted pyridines
Hommes, Paul,Berlin, Sarah,Reissig, Hans-Ulrich
, p. 3288 - 3294 (2013/12/04)
The intramolecular condensation of β-ketoenamides to 2- and/or 4-pyridone derivatives using either KOt-Bu or trimethylsilyl trifluoromethanesulfonate/Hu?nig's base was investigated. Subsequent nonaflation of the cyclization products allowed a facile purification and further functionalization through Suzuki-Miyaura couplings leading to new highly substituted pyridine derivatives. The dependence of the regioselectivity of cyclocondensation on the structure of the β-ketoenamides is discussed. Georg Thieme Verlag Stuttgart New York.
