15475-43-1 Usage
Uses
Used in Pharmaceutical Industry:
(1R,5S)-3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yloxy)-8-methyl-8-azabicyclo[3.2.1]octane (2Z)-but-2-enedioate is used as a potential pharmaceutical compound for its unique structure and stereochemistry, which may contribute to novel therapeutic effects and mechanisms of action.
Used in Biochemical Research:
In the field of biochemical research, (1R,5S)-3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yloxy)-8-methyl-8-azabicyclo[3.2.1]octane (2Z)-but-2-enedioate serves as a subject of study to understand its interactions with biological systems, potentially leading to the discovery of new biochemical pathways or targets for drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 15475-43-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,4,7 and 5 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 15475-43:
(7*1)+(6*5)+(5*4)+(4*7)+(3*5)+(2*4)+(1*3)=111
111 % 10 = 1
So 15475-43-1 is a valid CAS Registry Number.
15475-43-1Relevant academic research and scientific papers
Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein
Edink, Ewald,Akdemir, Atilla,Jansen, Chimed,Elk, René Van,Zuiderveld, Obbe,De Kanter, Frans J.J.,Van Muijlwijk-Koezen, Jacqueline E.,Smit, August B.,Leurs, Rob,De Esch, Iwan J.P.
, p. 1448 - 1454 (2012/04/04)
Using structure-based optimization procedures on in silico hits, dibenzosuberyl- and benzoate substituted tropines were designed as ligands for acetylcholine-binding protein (AChBP). This protein is a homolog to the ligand binding domain of the nicotinic acetylcholine receptor (nAChR). Distinct SAR is observed between two AChBP species variants and between the α7 and α4β2 nAChR subtype. The AChBP species differences are indicative of a difference in accessibility of a ligand-inducible subpocket. Hereby, we have identified a region that can be scrutinized to achieve selectivity for nicotinic receptor subtypes.
