154752-44-0Relevant academic research and scientific papers
ENANTIOSELECTIVE SYNTHESIS OF A STERICALLY HINDERED AMINE
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Page/Page column 25, (2008/06/13)
Compounds of the formula (I) wherein R is phenyl, or phenyl substituted by Cl, Br, C1-C4alkyl or CF3; R1 is H or methyl or ethyl; R2 is H or methyl or acyl; R3 is H or methyl; R'4/sub
Therapeutic agents
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, (2008/06/13)
The present invention provides a method of treating and preventing obesity and related co-morbid conditions comprising the administration of a therapeutically effective amount of one or more monoamine reuptake inhibitors which are serotonin reuptake inhibitors and/or noradrenaline reuptake inhibitors and a 5-HT1A agonist to a patient in need thereof.
First preparation of enantiomerically pure sibutramine and its major metabolite, and determination of their absolute configuration by single crystal X-ray analysis
Fang, Qun K.,Senanayake, Chris H.,Han, Zhengxu,Morency, Cynthia,Grover, Paul,Malone, Robert E.,Bulter, Hal,Wald, Stephen A.,Cameron, T. Stanley
, p. 4477 - 4480 (2007/10/03)
Racemic sibutramine was resolved with dibenzoyl-D-tartaric acid, and the absolute stereochemistry of sibutramine was determined by single crystal X- ray crystallography of its dibenzoyl D-tartrate. The major active metabolite (desmethylsibutramine) was ob
