229639-56-9Relevant articles and documents
New resolution approach for large-scale preparation of enantiopure didesmethylsibutramine (DDMS)
Han, Zhengxu,Krishnamurthy, Dhileepkumar,Fang, Q. Kevin,Wald, Stephen A.,Senanayake, Chris H.
, p. 3553 - 3556 (2003)
An improved synthesis and efficient resolution method to prepare both enantiopures of DDMS using crystallization of enantiomerically pure tartaric acid salts of racemic DDMS are disclosed.
PHENYLCYCLOBUTYLAMIDE DERIVATIVES AND THEIR STEREOISOMERS, THE PREPARING PROCESSES AND THE USES THEREOF
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Page/Page column 8, (2010/12/30)
Phenylcyclobutylamide derivatives and their optical isomers, the preparing processes and the uses thereof, which includes the compounds of formula (I), their pure stereoisomers and their pharmaceutically acceptable salts. In formula (I), R is H, formacyl,
A new and direct asymmetric synthesis of a hindered chiral amine via a novel sulfinate ketimine derived from N-tosyl-1,2,3-oxathiazolidme-2-oxide: Practical asymmetric synthesis of (R)-sibutramine
Han, Zhengxu,Krishnamurthy, Dhileepkumar,Senanayake, Chris H.
, p. 327 - 333 (2012/12/22)
A novel and direct approach for the asymmetric synthesis of (R)-sibutramine via chiral amine 5 using N-tosyl-1,2,3-oxathiazolidine-2-oxide (13) as a recyclable chiral auxiliary is described. Chiral sulfinate imine 16e was obtained by treatment of 13e with
