154770-67-9Relevant academic research and scientific papers
Indoles X: Synthesis, structure and D2-affinity of the β-carboline-analogue of flutroline
Lehmann,Knoch,Jiang
, p. 947 - 951 (2007/10/02)
10 is a β-carboline analogue of the neuroleptic flutroline(2a,b)) with significant lower affinity at the dopamine D2 binding site. Various synthetic routes to 10 and the solid state structure of 8 are described, structure activity relations, in particular the importance of the 'S-shape' and the rigid dopamine conformation are discussed.
