154776-46-2

Upstream product

• 437-30-9 4,4',4-trimethoxytrityl tetrafluoroborate 
• 49757-42-8 4,4',4''-trimethoxytrityl chloride 

Downstream Products

• 3010-81-9 tris(4-methoxyphenyl)methanol 
• 200626-04-6 N-Benzyl-4,4',4''-trimethoxytritylamine 
• 200626-06-8 N-Butyl-4,4',4''-trimethoxytritylamine 

Relevant academic research and scientific papers

Preparations, X-ray crystal structure determinations, and base strength measurements of substituted tritylamines

A range of tritylamines TrNRR′, and 4-methoxy-, 4,4′-dimethoxy-, and 4,4′,4″-trimethoxy-substituted analogues, have been prepared from (substituted) trityl chloride, bromide, or tetrafluoroborate with ammonia or with amines HNRR′ where R and R′ are hydrog

4,4′-Dimethoxytrityl and 4,4′,4″-trimethoxytrityl as protecting groups for amino functions; selectivity for primary amino groups and application in 15N-labelling

4,4′-Dimethoxytrityl tetrafluoroborate (DMT+ BF4-) and 4,4′,4″-trimethoxytrityl tetrafluoroborate (TMT+ BF4-) are useful reagents for protecting primary and some secondary amines. Protected amines are obtained either by reaction of DMT+ BF4- or TMT+ BF4- with the amine or by alkylating DMT- or TMT-amine (available from DMT+ BF4- and TMT+ BF4- by treatment with ammonia). Alkylation of DMT- or TMT-amine stops after monoalkylation. Deprotection of the alkylated DMT- and TMT-amine is achieved by treatment with an acid of appropriate molarity (e.g. 0.1 M HCl in 1:1 tetrahydrofuran-water for TMT-amines). The value of the methodology described is illustrated by a synthesis of (15NH2) adenosine. X-Ray molecular structures of one DMT and two TMT derivatives are reported.

N, N′ - Ditritylurea and analogs as hosts in crystalline clathrate complexes: Synthesis and selectivity studies

Of 38 hosts, most of them new, designed on the 'wheel-and-axle' model, 24 formed clathrate complexes with small molecules; 95 new host/guest combinations are described (Table 6). Selectivity studies (Table 7) show, in some instances, substantial discrimin