3010-81-9

Basic information

• Product Name: 4,4',4''-TRIMETHOXYTRITYL ALCOHOL
• Synonyms: 4,4',4''-TRIMETHOXYTRITYL ALCOHOL;4,4',4'-TRIMETHOXYTRITYL ALCOHOL;Benzenemethanol, 4-methoxy-alpha,alpha-bis(4-methoxyphenyl)-;Tris(4-methoxyphenyl)methanol;Tris(4-methoxyphenyl) carbinol~Tris(4-methoxyphenyl)methanol;Tris(4-methoxyphenyl)carbinol;4-Methoxy-α,α-bis(4-methoxyphenyl)benzenemethanol
• CAS NO: 3010-81-9
• Molecular Formula: C₂₂H₂₂O₄
• Molecular Weight: 350.41
• EINECS: 221-139-5
• Mol File: 3010-81-9.mol
• Article Data: 24

Chemical Properties

• Melting Point: 76-77°C
• Boiling Point: 522.1°Cat760mmHg
• Flash Point: 269.6°C
• Appearance: /
• Density: 1.159g/cm³
• PKA: 12.94±0.29(Predicted)
• BRN: 1890559
• CAS DataBase Reference: 4,4',4''-TRIMETHOXYTRITYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4',4''-TRIMETHOXYTRITYL ALCOHOL(3010-81-9)
• EPA Substance Registry System: 4,4',4''-TRIMETHOXYTRITYL ALCOHOL(3010-81-9)

Safety Data

• Hazardous Substances Data: 3010-81-9(Hazardous Substances Data)

Usage

General Description

4,4',4''-trimethoxytrityl alcohol is a compound commonly used as a protecting group for alcohols in organic synthesis. It is a white crystalline solid that is soluble in organic solvents. This chemical is utilized in the synthesis of various pharmaceuticals and organic compounds by temporarily protecting the hydroxyl group of alcohols, thereby preventing unwanted reactions during the synthesis process. Upon completion of the desired reactions, the protecting group can be easily removed using mild acidic conditions. 4,4',4''-trimethoxytrityl alcohol plays a crucial role in the efficient and selective synthesis of complex organic molecules in the pharmaceutical and chemical industries.

Upstream product

• 7511-68-4 tris(4-methoxyphenyl)methane 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 49757-42-8 4,4',4''-trimethoxytrityl chloride 
• 19920-04-8 tetrakis-(4-methoxy-phenyl)-ethanone 
• 94-36-0 dibenzoyl peroxide 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 121-98-2 methyl 4-methoxybenzoate 
• 7664-93-9 sulfuric acid 
• 200626-06-8 N-Butyl-4,4',4''-trimethoxytritylamine 
• 200626-04-6 N-Benzyl-4,4',4''-trimethoxytritylamine 
• 90-96-0 bis(p-methoxyphenyl)methanone 
• 28550-87-0 Tris-(4-methoxy-phenyl)-methyl 
• 100-07-2 4-methoxy-benzoyl chloride 
• 1046457-48-0 4,4',4''-trimethoxytrityl 2,2,2-trifluoroethyl ether 

Downstream Products

• 7511-68-4 tris(4-methoxyphenyl)methane 
• 49757-42-8 4,4',4''-trimethoxytrityl chloride 
• 83425-83-6 1,1,1-tris(4-methoxyphenyl)ethane 
• 14039-13-5 C₂₂H₂₁O₃⁽¹⁺⁾ 
• 603-44-1 4,4',4''-methylidynetrisphenol 
• 13561-40-5 N--benzolsulfonamid 
• 69897-71-8 (4,4',4''-Trimethoxytriphenyl)-methyl-n-propylsulfid 
• 69897-70-7 (4,4',4''-Trimethoxytriphenyl)-methylethylether 
• 28550-87-0 Tris-(4-methoxy-phenyl)-methyl 
• 71227-30-0 1-Phenyl-2,2,2-tris-(p-methoxyphenyl)-aethanon 
• 37964-78-6 tris(4-methoxyphenyl)acetonitrile 

Relevant articles and documents

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Temperature-Dependent Reactivity of a Non-heme FeIII(OH)(SR) Complex: Relevance to Isopenicillin N Synthase

Non-heme iron complexes with cis-FeIII(OH)(SAr/OAr) coordination were isolated and examined for their reactivity with a tertiary carbon radical. The sulfur-ligated complex shows a temperature dependence on ?OH versus ArS? transfer, whereas the oxygen-ligated complex does not. These results provide the first working model for C-S bond formation in isopenicillin N synthase and indicate that kinetic control may be a key factor in the selectivity of non-heme iron "rebound"processes.

Dioxygen-Derived Nonheme Mononuclear FeIII(OH) Complex and Its Reactivity with Carbon Radicals

A new tetradentate, monoanionic, mixed N/O donor ligand (BNPAPh2O-) with second coordination sphere H-bonding groups has been synthesized for stabilization of a terminal FeIII(OH) complex. The complex FeII(BNPAPh2O)(OTf) (1) reacts with O2 to give a mononuclear terminal FeIII(OH) complex, FeIII(OH)(BNPAPh2O)(OTf) (2), both of which were characterized by X-ray diffraction, electrospray ionization mass spectrometry, UV-vis, 1H and 19F nuclear magnetic resonance, 57Fe M?ssbauer, and electron paramagnetic resonance spectroscopies. Treatment of 2 with carbon radicals (Ar3C·) gives Ar3COH and the FeII complex 1, in direct analogy with the elusive radical "rebound" process proposed for nonheme iron enzymes.