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Usage

Uses

Used in Pharmaceutical Research:
(5-BROMO-1-BENZOFURAN-2-YL)(PHENYL)METHANONE is used as a key intermediate in the synthesis of new drugs for various therapeutic applications. The presence of the bromine and benzofuran moieties makes it a promising candidate for drug discovery, as they can improve the compound's interaction with specific biological targets.
Used in Agrochemical Development:
In the agrochemical industry, (5-BROMO-1-BENZOFURAN-2-YL)(PHENYL)METHANONE is used as a building block for the development of new agrochemicals. Its unique structure and functional groups can be exploited to create compounds with enhanced biological activity and selectivity, potentially leading to more effective and environmentally friendly products.
Used in Materials Science:
(5-BROMO-1-BENZOFURAN-2-YL)(PHENYL)METHANONE also has potential applications in materials science, where its unique structure and properties can be utilized to develop new materials with specific characteristics. (5-BROMO-1-BENZOFURAN-2-YL)(PHENYL)METHANONE's versatility in terms of derivatization and modification makes it an attractive candidate for research in this field.
It is important to handle and use (5-BROMO-1-BENZOFURAN-2-YL)(PHENYL)METHANONE with caution, following proper safety protocols and regulations to ensure the safety of researchers and the environment.

Upstream product

• 644-78-0 2-hydroxychalcone 
• 98-86-2 acetophenone 
• 1761-61-1 5-bromosalicyclaldehyde 
• 18287-99-5 (E)-3-(5-bromo-2-hydroxyphenyl)-1-phenylprop-2-en-1-one 
• 532-27-4 1-chloroacetophenone 
• 70-11-1 α-bromoacetophenone 
• 4636-16-2 iodoacetophenone 

Downstream Products

• 1262243-50-4 (R)-(5-bromobenzofuran-2-yl)(phenyl)methanol 
• 82158-29-0 (5-bromobenzofuran-2-yl)(phenyl)methanol 

Relevant academic research and scientific papers

Reaction of chalcones with NBS, a simple one pot synthesis of 2-aroylbenzo[b]furanes

A simple one pot synthesis of 2-aroylbenzo[b]furanes has been achieved by bromomethoxylation with NBS and subsequent treatment of the appropriately substituted 2-hydroxychalcones with sodium hydroxide.

Synthesis method of benzofuran compound

The invention belongs to the field of organic chemical synthesis, and particularly relates to a synthesis method of a benzofuran compound. According to the invention, the reaction system adopts economical and efficient iron phthalocyanine as a catalyst, a

Copper(I)-Catalyzed Chemoselective Reduction of Benzofuran-2-yl Ketones to Alcohols with B2pin2 via a Domino-Borylation-Protodeboronation Strategy

A novel copper(I)-catalyzed chemoselective reduction of the carbonyls of benzofuran-2-yl ketones over furan rings with B2pin2 has been developed. This reaction proceeded under mild conditions. High valuable secondary alcohol derivatives of benzofurans were obtained in good to excellent yields with a broad substrate scope. The mechanistic studies suggested that a domino-borylation-protodeboronation pathway was involved in this reaction.

Intramolecular oxidative coupling: I2/TBHP/NaN3-mediated synthesis of benzofuran derivatives

A novel intramolecular oxidative coupling reaction has been established to prepare benzofuran derivatives via direct C(sp2)-H functionalization for the formation of C-O bond. This transformation is mediated by I2/TBHP/NaN3 under metal-free conditions and a catalytic amount of NaN3 plays a crucial role in the reaction. Furthermore, the reaction tolerates a broad substrate scope with average to excellent yields.

Synthesis and antitubercular activity of 4-thiazolidinone derivatives incorporating benzofuran moiety

5-Bromo-1-benzofuran-2-yl(substituted phenyl) methanones (2a-e) were prepared by the reaction of 2-bromo-1-(phenyl) ethanones and 5-bromosalicylaldehyde in dimethylformamide in the presence of anhydrous potassium carbonate to maintain basic condition. Con

Reaction products of 5-bromobenzofuran-2-yl-aryl methanone and their antimicrobial activities

5-Bromobenzofuran-2-yl-aryl methanones (2a-e) were obtained by the reaction of 5-bromosalicylaldehyde 1 with 2-bromo-1-(aryl) ethanones. The condensation of compounds (2a-e) with hydroxylamine hydrochloride, thiosemicarbazide and aromatic amine such as an

DMAP-catalyzed cascade reaction: One-pot synthesis of benzofurans in water

A series of benzofurans were efficiently synthesized in good to excellent yields using 4-dimethylaminopyridine (DMAP) catalyzed cascade reaction between salicylaldehydes and halogenated ketones in water at 80 °C opened atmosphere.

An expedient synthesis of enantioenriched substituted (2-benzofuryl) arylcarbinols via tandem Rap-Stoermer and asymmetric transfer hydrogenation reactions

An expedient synthesis of enantioenriched substituted (benzofuran-yl)-aryl and heteroaryl carbinols, is described. A key feature of this protocol is synthesis of functionally varied benzofuran scaffolds via a Rap-Stoermer reaction/catalytic asymmetric tra

Microwave-mediated solvent free Rap-Stoermer reaction for efficient synthesis of benzofurans

The Rap-Stoermer reaction of salicylaldehydes with diverse phenacyl bromide and phenacyl iodides proceeded cleanly to afford various functionalized benzofurans in excellent yields under base-mediated solvent free microwave irradiation conditions.

Synthesis of 2-, 4- And 5-(2-alkylcarbamoyl-l-methylvinyl)-7- alkyloxybenzo[b]furans and their leukotriene 64 receptor antagonistic activity

Variable benzo[6]furan derivatives having (E)- and (Z)-2-alkylcarbamoyl-l- methylvinyl groups at the 2-, 4- and 5-positions and a carboxylpropoxy or (1-phenyl)ethoxy group at the 7-position were prepared to find novel and selective leukotriene B4 (LTB4) receptor antagonists. (E)-2-(2-Diethylcarbamoyl- l-methylvinyl)-7-(1-phenylethoxy)benzo[b]furan (4v) showed selective inhibition to the human BLT2 receptor (hBLT2). On the other hand, (E)-2-acetyl-4-(2-diethylcarbamoyl-l-methylvinyl)-7-(l-phenylethoxy)benzo[b] furan (7v) inhibited both human BLTi receptor (hBLT1) and hBLT 2. The (E)-2-(2-diethylcarbamoyl-l-methylvinyl) group lay on approximately the same plane as the benzo[e]furan ring, whereas the (E)-4-(2-diethylcarbamoyl-l-methylvinyl) group had the torsion angle (45.7°) from the benzo[e]furan ring plane. However, the (Z)-(2-alkylcarbamoyl-l- methylvinyl)benzo[b]furans were inactive. The inhibitory activity depended on the conformation of the 2-diethylcarbamoyl-l-methylvinyl group. The Royal Society of Chemistry 2005.