154822-31-8

Basic information

• Product Name: 3-hydroxy-7-methoxy-2-phenyl-3-(4-pyridyl)-2,3-dihydro-1H-isoindolin-1-one
• Synonyms: 3-hydroxy-7-methoxy-2-phenyl-3-(4-pyridyl)-2,3-dihydro-1H-isoindolin-1-one
• CAS NO: 154822-31-8
• Molecular Weight: 332.359
• Mol File: 154822-31-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-7-methoxy-2-phenyl-3-(4-pyridyl)-2,3-dihydro-1H-isoindolin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-7-methoxy-2-phenyl-3-(4-pyridyl)-2,3-dihydro-1H-isoindolin-1-one(154822-31-8)
• EPA Substance Registry System: 3-hydroxy-7-methoxy-2-phenyl-3-(4-pyridyl)-2,3-dihydro-1H-isoindolin-1-one(154822-31-8)

Safety Data

• Hazardous Substances Data: 154822-31-8(Hazardous Substances Data)

Upstream product

• 1903-64-6 N,N-dimethylisonicotineamide 
• 6833-21-2 2-methoxy-N-phenylbenzamide 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 

Relevant articles and documents

Application of organolithium and related reagents in synthesis. Part 23: Synthetic strategies based on ortho-aromatic metallation. Synthesis of 4b- arylisoindolo[2,1-a]quinoline derivatives

The synthesis of the 2-aryl-3-hydroxyisoindol-1-ones 3 and their successive conversion via the reaction with 1-methoxy-1- trimethylsilyloxyethene in the presence of titanium(IV) chloride into 3- carboxymethylphthalimides 7 and subsequent cyclization via sequential treatment with oxalyl chloride and aluminium chloride as a way of regiospecific transformation of the benzenecarbocylic acids into the corresponding isoindolo[2,1-a]quinoline-5, 11-diones 5 is described. (C) 2000 Elsevier Science Ltd.

Application of organolithium and related reagents in synthesis. Part 14. Synthetic strategies based on aromatic metallation. A concise regiospecific conversion of benzole acids into their ortho-pyridoyl derivatives

The synthesis of the 3-hydroxy-3-pyridyl-isoindolin-1-ones (5) and (6) via metallation (n-BuLi) of the benzanilides (1), and then the reaction of the generated bis lithiated anilides (2) with N,N-dimethylamides or methyl esters of pyridinecarboxylic acids (benzoylation reagents), and subsequent acidic hydrolysis of (5) and (6) as a way (general synthetic strategy) of regiospecific transformation of benzoic acids into their ortho-benzoylated derivatives, is described.