1903-64-6

Basic information

• Product Name: 4-Pyridinecarboxamide,N,N-dimethyl-(9CI)
• Synonyms: 4-Pyridinecarboxamide,N,N-dimethyl-(9CI);N,N-dimethylisonicotinamide;N,N-dimethylpyridine-4-carboxamide
• CAS NO: 1903-64-6
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.1778
• Product Categories: AMIDE
• Mol File: 1903-64-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 283.9°Cat760mmHg
• Flash Point: 125.5°C
• Appearance: /
• Density: 1.088g/cm³
• Vapor Pressure: 0.00308mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: 4-Pyridinecarboxamide,N,N-dimethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinecarboxamide,N,N-dimethyl-(9CI)(1903-64-6)
• EPA Substance Registry System: 4-Pyridinecarboxamide,N,N-dimethyl-(9CI)(1903-64-6)

Safety Data

• Hazardous Substances Data: 1903-64-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H10N2O/c1-10(2)8(11)7-3-5-9-6-4-7/h3-6H,1-2H3

Upstream product

• 55-22-1 pyridine-4-carboxylic acid 
• 124-40-3 dimethyl amine 
• 68-12-2 N,N-dimethyl-formamide 
• 694-59-7 pyridine N-oxide 
• 872-85-5 pyridine-4-carbaldehyde 
• 14254-57-0 4-(chlorocarbonyl)pyridine 

Downstream Products

• 13841-66-2 butyl isonicotinate 
• 154822-32-9 3-hydroxy-3-(pyridin-4-yl)-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one 
• 530-40-5 N,N-diethylisonicotinamide 
• 154822-31-8 3-hydroxy-7-methoxy-2-phenyl-3-(4-pyridyl)-2,3-dihydro-1H-isoindolin-1-one 
• 154822-34-1 3-hydroxy-4-methoxy-2-phenyl-3-(4-pyridyl)-2,3-dihydro-1H-isoindolin-1-one 

Relevant articles and documents

POCl3 promoted metal-free synthesis of tertiary amides by coupling of carboxylic acids and N,N-disubstituted formamides

Herein we report a robust and synthetically useful catalyst-free amination methodology by the coupling of carboxylic acids and N-substituted formamides using POCl3 as a promoter. Versatile amides with a wide array of substituent groups were prepared within only 1 h in good to excellent yields. And even multi-substituted aromatic carboxylic acids could give the desired products with satisfactory results.

Preparation of Thioanisole Biscarbanion and C-H Lithiation/Annulation Reactions for the Access of Five-Membered Heterocycles

The synthesis, isolation, and X-ray structure of a thioanisole-based trilithium complex are reported. On the basis of the double-lithiation strategy, two novel synthetic methodologies have been developed under mild reaction conditions (room temperature): (1) reactions of lithiated thioanisoles with nitriles give benzoisothiazoles via a [3 + 2]-type of approach with two new bond formations and (2) formation of benzothiophenes from thioanisoles and amides through a [4 + 1] pattern forming 4 new chemical bonds.

Method for synthesizing phosphorus-oxychloride-promoted amide compound

The invention relates to a method for synthesizing a phosphorus-oxychloride-promoted amide compound. The synthesizing method includes the steps that carboxylic acid serves as one reactant, another reactant (N,N-dialkyl methanamide) serves as a solvent, one equivalent of phosphorus oxychloride is added, and the amide compound is prepared. The reaction substrates are low in price and easy to get, the nature is stable, toxicity is small, the reaction speed is high, conditions are moderate, and the reaction substrates can be widely applied to substrates with different functional groups. The efficiently-constructed amide compound is an important molecular skeleton for many medicines, bioactive molecules and natural products, and the synthesizing method is a widely-applicable preparing method for synthesizing the compound.