1548227-78-6

Basic information

• Product Name: 1-(4-hydroxyphenyl)-3-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one
• Synonyms: 1-(4-hydroxyphenyl)-3-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one
• CAS NO: 1548227-78-6
• Molecular Weight: 244.293
• Mol File: 1548227-78-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-hydroxyphenyl)-3-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-hydroxyphenyl)-3-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one(1548227-78-6)
• EPA Substance Registry System: 1-(4-hydroxyphenyl)-3-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one(1548227-78-6)

Safety Data

• Hazardous Substances Data: 1548227-78-6(Hazardous Substances Data)

Upstream product

• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 2125-51-1 3-dimethylamino-1-(p-hydroxyphenyl)-1-propanone hydrochloride 

Downstream Products

• 1548227-88-8 ClH*C₁₇H₂₃N₃O₂ 
• 1548227-98-0 ClH*C₁₉H₂₅N₃O₃ 

Relevant articles and documents

Utility of Ketonic Mannich Bases in Synthesis of Some New Functionalized 2-Pyrazolines

The styryl ketonic Mannich base 2 has been used as a precursor in the synthesis of 2-pyrazolines having a basic side chain at C-3 and a phenolic Mannich base at C-5. Treatment of the bis(styryl ketonic bases) 6a and 8a with phenylhydrazine affords the bis(3-functionalized 2-pyrazolines) 7 and 9. The transamination between the styryl keto base 10 and 4-aminoantipyrine leads to 12, which reacts with piperazine to give 13. N-Nitrosation of the sec-Mannich bases 15a–d followed by reductive cyclization affords 2-pyrazolines 17a–d. The keto base 14b has been used for the synthesis of 2-pyrazolines having a phenolic Mannich base at C-3 and its reaction with 3,5-dimethyl-1H-pyrazole affords 23. The alkylation of 3-methyl-1-phenyl-2-pyrazolin-5-one with the bis(Mannich base) 25 was investigated.