Cas 1548334-22-0,4-((2S,4S)-2-(5-chloro-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-fluoropyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

1548334-22-0

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Basic information

Product Name: 4-((2S,4S)-2-(5-chloro-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-fluoropyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
Synonyms:
CAS NO:1548334-22-0
Molecular Formula:
Molecular Weight: 474.884
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 4-((2S,4S)-2-(5-chloro-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-fluoropyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile(CAS DataBase Reference)
NIST Chemistry Reference: 4-((2S,4S)-2-(5-chloro-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-fluoropyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile(1548334-22-0)
EPA Substance Registry System: 4-((2S,4S)-2-(5-chloro-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-fluoropyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile(1548334-22-0)

Safety Data

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Safety Statements: N/A
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RTECS:
HazardClass: N/A
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Hazardous Substances Data: 1548334-22-0(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1548334-22-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,4,8,3,3 and 4 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1548334-22:
(9*1)+(8*5)+(7*4)+(6*8)+(5*3)+(4*3)+(3*4)+(2*2)+(1*2)=170
170 % 10 = 0
So 1548334-22-0 is a valid CAS Registry Number.

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1548334-22-0Relevant academic research and scientific papers

Discovery, Optimization, and Evaluation of Potent and Highly Selective PI3Kγ-PI3KδDual Inhibitors

Jia, Hong,Dai, Guangxiu,Su, Weiguo,Xiao, Kun,Weng, Jianyang,Zhang, Zhulin,Wang, Qing,Yuan, Tianhai,Shi, Fuying,Zhang, Zheng,Chen, Wei,Sai, Yang,Wang, Jian,Li, Xiong,Cai, Yu,Yu, Jun,Ren, Ping,Venable, Jennifer,Rao, Tadimeti,Edwards, James P.,Bembenek, Scott D.

, p. 4936 - 4948 (2019/05/28)

An electronic density model was developed and used to identify a novel pyrrolotriazinone replacement for a quinazolinone, a commonly used moiety to impart selectivity in inhibitors for PI3Kγand PI3Kδ. Guided by molecular docking, this new specificity piece was then linked to the hinge-binding region of the inhibitor using a novel cyclic moiety. Further structure-activity relationship optimization around the hinge region led to the discovery of candidate 26, a highly potent and selective PI3Kγ-PI3Kδdual inhibitor with favorable drug metabolism and pharmacokinetic properties in preclinical species.

NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS

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Page/Page column 47; 86, (2014/02/16)

Provided are novel heteroaryl and heterocycle compounds of formula (I-1), (I-2) or (I-3) and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3K and for treating inflammatory and autoimmune disorders diseases and cancer.

NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS

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Page/Page column 38; 63, (2014/02/16)

The invention relates to novel heteroaryl and heterocycle compounds and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3k and for treating inflammatory and autoimmune disorders diseases and cancer.

NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITION AND METHODS THEREOF

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Page/Page column 49; 86, (2014/02/16)

Disclosed are novel heteroaryl and heterocycle compounds of formula I-1, I-2 or I-3 and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3K and for treating inflammatory and autoimmune diseases and cancer.

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