154843-27-3Relevant academic research and scientific papers
New Findings on the Vilsmeier-Haack Approach to Quinoline Derivatives
Alonso, Miguel Angel,Ubeda, J. Ignacio,Avendano, Carmen,Menendez, J. Carlos,Villacampa, Mercedes
, p. 10997 - 11008 (2007/10/02)
The presence of electron-releasing substituents on the aromatic ring of anilides, although necessary for the Vilsmeier-Haack cyclization to quinolines to proceed efficiently, can cause failure of the expected cyclization, leading to (Z) N,N-dimethylformamidines through an alternative course.A similar behaviour is observed when ?-donor groups are introduced on the α position of the anilide, although in this case some cyclization to quinoline derivatives generally occurs.
