15485-32-2

Upstream product

• 106-49-0 p-toluidine 
• 873-76-7 para-Chlorobenzyl alcohol 
• 33863-79-5 N-(4-chlorobenzyl)-4-methylbenzeneamine 
• 99-99-0 1-methyl-4-nitrobenzene 
• 104-88-1 4-chlorobenzaldehyde 
• 104-86-9 4-chlorobenzylamine 

Downstream Products

• 62500-38-3 (3R,4S)-4-(4-Chloro-phenyl)-3-phenyl-1-p-tolyl-azetidin-2-one 
• 104-88-1 4-chlorobenzaldehyde 
• 501-60-0 1,2-di(p-tolyl)diazene 
• 96541-52-5 2-(4-methylanilino)-2-(4-chlorophenyl)acetonitrile 
• 613-33-2 (4,4'-dimethyl-1,1'-biphenyl) 
• 1254576-63-0 N-(p-tolyl)-1-[4-(p-tolyl)phenyl]methanimine 
• 1263433-11-9 C₂₀H₂₁ClN₂O 
• 1336883-82-9 2,2-dichloro-3-(4-chlorophenyl)-1-(4-methylphenyl)aziridine 
• 1353765-11-3 N-(4-chlorophenyl)-N-(4-methylbenzyl)acetamide 
• 1353765-17-9 C₁₇H₁₈ClNO 
• 22699-29-2 4-chlorobenzaldehyde N,N-dimethylhydrazone 
• 1381802-31-8 4-amino-5-(4-chlorophenyl)-3-phenyl-1-p-tolyl-1H-pyrrol-2(5H)-one 

Relevant academic research and scientific papers

Molecular Conformation and Electronic Structure. VII. The Structure of the Isomorphic System p-Chloro-N-(p-methylbenzylidene)aniline and p-Methyl-N-(p-chlorobenzylidine)aniline

The isomorphous crystal structures of two hetero para disubstituted derivatives of benzylideneaniline, BA, have been determined.Both p-chloro-N-(p-methylbenzylidene)aniline, MeCl, and p-methyl-N-(p-chlorobenzylidene)aniline, ClMe, (C14H12ClN, Mr/sub

Synthesis of Green/Blue Light Emitting Quinolines by Aza-D-A Reaction Using InCl3 Catalyst

An efficient InCl3-catalyzed sequential reaction of aromatic amines, aromatic aldehydes and functionalized alkynes leading to the formation of new quinoline derivatives exhibiting significant fluorescence activities is described. The photophysi

Synthesis and characterization of tetrachloro-1,3-oxazepine derivatives and evaluation of their biological activities

6,7,8,9-Tetrachloro[1,3]oxazepine-1,5-dione derivatives 1b-10b have been synthesized by reacting Schiff bases 1a-10a with tetrachlorophthalic anhydride (TCPA) under (2 + 5 → 7) cycloaddition reaction conditons. All reactions had been monitored using TLC.

Dehydrogenation and α-functionalization of secondary amines by visible-light-mediated catalysis

A visible-light-mediated process for dehydrogenation of amines has been described. The given protocol showed a broad substrate scope, mild reaction conditions and excellent results without the requirement of tedious purification. This process can be applied in one-pot functionalization of secondary amines with various nucleophiles through the cooperation of visible-light and Lewis acid catalysis, leading to the structurally varied essential components of biologically active molecules. In addition, Stern-Volmer studies and quenching experiments revealed the role of a catalyst and led to the proposed mechanism of this transformation.

Visible light photocatalytic aerobic oxidative synthesis of imines from alcohols and amines on dye-sensitized TiO2

A general visible light photocatalytic protocol for the synthesis of imines via a two-step one-pot route on alizarin red S (ARS)-sensitized TiO2 was uncovered. This efficient synthesis protocol involves one step of the highly selective formation of aldehydes from the oxidation of alcohols with O2 on ARS-sensitized TiO2 photocatalyst, and a subsequent step of condensation of newly formed aldehydes with various amines on TiO2 to afford imines in one pot. Anatase TiO2 provides a versatile platform for catalytic amounts of ARS (0.67 mol%) to facilitate the electron transfer from dye traversing its conduction band to O2 under green LED irradiation. Moreover, the Lewis acid sites of TiO2 can promote the formation of imines from aldehydes and amines in very high isolated yields. We took advantage of both the photocatalytic and catalytic properties of TiO2 to significantly expand the scope of imines. Our work suggests that the synthetic applications of TiO2 photocatalysis can be achievable under mild conditions by exploring the excellent functionalities of TiO2.

FeCl3-Mediated One-Pot Cyclization–Aromatization of Anilines, Benzaldehydes, and Phenylacetylenes under Ball Milling: A New Alternative for the Synthesis of 2,4-Diphenylquinolines

A straightforward and efficient method has been developed for the solvent-free synthesis of 2,4-diphenylquinolines via a one-pot reaction of anilines, benzaldehydes, and phenylacetylenes promoted by FeCl3 under solvent-free mechanochemical ball

Design and stereoselective synthesis of novel β-lactone and β-lactams as potent anticancer agents on breast cancer cells

To produce a novel class of anticancer compounds, an efficient method for synthesizing novel β-lactone and β-lactam frameworks was developed based on the reaction of a new ketene with C=O and C=N bonds. Functionalized 2-azetidinones were efficiently synthesized by employing 2,4-dichlorophenoxylketene, which was generated in situ. The reaction of the ketene with aldehydes was not successful and in all cases except for 4-nitrobenzaldehyde, a rearranged dimer of the ketene was obtained as a lactone. Anticancer cellular activity of all new β-lactams and lactones on breast cancer cells was studied. All new synthesized compounds exhibited potential anticancer activity which may guarantee their future application in moderate chemotherapy.

Direct synthesis of imines by 9-azabicyclo-[3,3,1]nonan-N-oxyl/KOH-catalyzed aerobic oxidative coupling of alcohols and amines

A simple and efficient method for preparation of imines by the oxidative coupling of benzyl alcohols with aromatic amines or aliphatic amines was developed. The reaction was catalyzed by 9-azabicyclo[3.3.1]nonan-N-oxyl (ABNO)/KOH with air as the economic and green oxidant. Under the optimal reaction conditions, a variety of imines were obtained in 80%-96% isolated yields.

Unsymmetrical indazolyl-pyridinyl-triazole ligand-promoted highly active iridium complexes supported on hydrotalcite and its catalytic application in water

Herein, an indazolyl-pyridinyl-triazole ligand was synthesized and its iridium complex supported on hydrotalcite was characterized via X-ray power diffraction (XRD), X-ray photoelectron spectroscopy (XPS), energy dispersive X-ray (EDX) spectroscopy and transmission electron microscopy (TEM). This new heterogeneous catalyst bearing the unsymmetrical indazolyl-pyridinyl-triazole ligand exhibits high catalytic activity in water. Both functionalized amines and imines were obtained from the challenging selective reaction of benzylamines with arylamines through transfer hydrogenation and dehydrogenation under clean conditions. In particular, it was observed that this catalyst system showed good recovery performance in water. Mechanistic studies showed that this transformation occurs via amine dehydrogenation, hydrolysis and condensation processes. The direct capture of the reaction intermediate provides sufficient proof for this process.

Synthesis of secondary amines by reductive amination of aldehydes with nitroarenes over supported copper catalysts in a flow reactor

Supported copper catalysts were investigated for the one-pot reductive amination of aldehydes with nitroarenes in a continuous flow reactor. This process is considered advantageous compared to current traditional methods, which present several drawbacks, such as toxicity of reducing or alkylation agent, lack of monoalkylation selectivity and large amounts of waste produced. Various secondary amines were synthesized in good to excellent yields in the reactions of aliphatic aldehydes with nitroarenes using molecular hydrogen as a reducing agent. It was found that the yield of secondary amine depends on the rate of formation of intermediate imine.