154902-46-2

Upstream product

• 154902-45-1 (1R,2S)-1-(meta-trifluoromethylphenyl)-2,3-epoxypropan-1-ol 
• 154309-48-5 1-<3-(trifluoromethyl)phenyl>prop-2-en-1-ol 
• 154902-43-9 (S)-1-(meta-trifluoromethylphenyl)-2-propen-1-ol 

Downstream Products

• 618-97-3 1-<3-(trifluoromethyl)phenyl>propan-1-ol 
• 135561-75-0 (S)-1-[(3′-trifluoromethyl)phenyl]-2-propanol 

Relevant academic research and scientific papers

Asymmetric syntheses of (S)-Fenfluramine using Sharpless Epoxidation Methods

We describe one synthesis of (S)-fenfluramine and several syntheses of its precursors (R)- and (S)-1-(meta-trifluoromethylphenyl)propan-2-ols.They were obtained from the asymmetric epoxidation of the primary allylic alcohol 5 and from the kinetic resolution with asymmetric epoxidation of teh secondary allylic alcohol 6.