135561-75-0Relevant articles and documents
Enabling catalytic ketone hydrogenation by frustrated lewis pairs
Mahdi, Tayseer,Stephan, Douglas W.
, p. 15809 - 15812 (2014)
Hydrogenation of alkyl and aryl ketones using H2 is catalytically achieved in 18 examples using 5 mol % B(C6F5)3 in an ethereal solvent. In these cases the borane and ether behave as a frustrated Lewis pair to activate H2 and effect the reduction.
Expanding the Substrate Specificity of Thermoanaerobacter pseudoethanolicus Secondary Alcohol Dehydrogenase by a Dual Site Mutation
Musa, Musa M.,Bsharat, Odey,Karume, Ibrahim,Vieille, Claire,Takahashi, Masateru,Hamdan, Samir M.
, p. 798 - 805 (2018/02/21)
Here, we report the asymmetric reduction of selected phenyl-ring-containing ketones by various single- and dual-site mutants of Thermoanaerobacter pseudoethanolicus secondary alcohol dehydrogenase (TeSADH). The further expansion of the size of the substrate binding pocket in the mutant W110A/I86A not only allowed the accommodation of substrates of the single mutants W110A and I86A within the expanded active site but also expanded the substrate range of the enzyme to ketones bearing two sterically demanding groups (bulky–bulky ketones), which are not substrates for the TeSADH single mutants. We also report the regio- and enantioselective reduction of diketones with W110A/I86A TeSADH and single TeSADH mutants. The double mutant exhibited dual stereopreference to generate the Prelog products most of the time and the anti-Prelog products in a few cases.
Nickel-Catalyzed C-Alkylation of Nitroalkanes with Unactivated Alkyl Iodides
Rezazadeh, Sina,Devannah, Vijayarajan,Watson, Donald A.
supporting information, p. 8110 - 8113 (2017/06/28)
Enabled by nickel catalysis, a mild and general catalytic method for C-alkylation of nitroalkanes with unactivated alkyl iodides is described. Compatible with primary, secondary, and tertiary alkyl iodides; and tolerant of a wide range of functional groups, this method allows rapid access to diverse nitroalkanes.