152533-46-5Relevant articles and documents
Enantioselective approach to 7-azabicyclo[2.21lheptane ring systems using D-(-)quinic acid as the chiral educt: Application to the formal synthesis of (+)-epibatidine
Albertini, Enrichetta,Barco, Achille,Benetti, Simonetta,De Risi, Carmela,Pollini, Gian P.,Zanirato, Vinicio
, p. 681 - 684 (1997)
By utilizing, D-(-)-quinic acid as the chiral starting material the optically pure 7-[(1,1-dimethylethoxy)carbonyl]-7-azabicyclo[ 2.2.1]heptan-2-one 2, an advanced intermediate already taken to (+)-epibatidine 1, a non-opioid analgesic isolated from Ecuadorian poison frogs, was synthetized through a facile, regioselective intramolecular nucleophilic ring opening of a cyclic sulfate moiety.
PROTEASOME ACTIVITY ENHANCING COMPOUNDS
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Page/Page column 160; 163; 198-199, (2020/01/24)
The present invention is directed towards compounds having the Formula (lb) or the Formulae (III) and pharmaceutically acceptable salts, solvates and clathrates thereof, compositions thereof, as well as towards the use of said compounds in methods for the treatment of a condition associated with a dysfunction in proteostasis.
Substituted Imidazopyridines as HDM2 Inhibitors
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, (2014/07/08)
The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.