154920-43-1Relevant articles and documents
Antisense modulation of MDM2 expression
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, (2008/06/13)
Compounds, compositions and methods are provided for inhibiting the expression of human mdm2. The compositions include antisense compounds targeted to nucleic acids encoding mdm2. Methods of using these oligonucleotides for inhibition of mdm2 expression and for treatment of diseases such as cancers associated with overexpression of mdm2 are provided.
Synthesis of 2'-deoxyguanosine containing a N2-polyamine
Ramasamy,Bakir,Baker,Dan Cook
, p. 1373 - 1377 (2007/10/02)
The synthesis of benzylated N2-(4,7,10,13-tetraazatridec-1-yl)-2'- deoxyguanosines 4 was accomplished by a key nucleophilic reaction of the novel unsymmetrical polyamine 2, with 3',5'-O-(tetraisopropyldisiloxane-1,3- diyl)-2-chloro-2'-deoxyinos