1549752-27-3Relevant academic research and scientific papers
Unsymmetrical 1,5-diaryl-3-oxo-1,4-pentadienyls and their evaluation as antiparasitic agents
Ud Din, Zia,Fill, Taicia Pacheco,De Assis, Francisco Favaro,Lazarin-Bidóia, Danielle,Kaplum, Vanessa,Garcia, Francielle Pelegrin,Nakamura, Celso Vataru,De Oliveira, Kleber Thiago,Rodrigues-Filho, Edson
, p. 1121 - 1127 (2014/02/14)
In this work the synthesis and antiparasitical activity of new 1,5-diaryl-3-oxo-1,4-pentadienyl derivatives are described First, compounds 1a, 1b, 1c and 1d were prepared by acid-catalyzed aldol reaction between 2-butanone and benzaldehyde, anisaldehyde, p-N,N-dimethylaminobenzaldehyde and p-nitrobenzaldehyde Reacting each of the methyl ketones 1a, 1b, 1c and 1d with the p-substituted benzaldehydes under basic-catalyzed aldol reaction, we further prepared compounds 2a-2p All twenty compounds were evaluated for antiproliferative activity, particularly for promastigote of Leishmania amazonensis and epimastigote of Trypanosoma cruzi All compounds showed good activity while nitro compounds 2i and 2k showed inhibition activity at a few μM
