154976-48-4Relevant academic research and scientific papers
General Approach to the Synthesis of Specifically Deuterium-Labeled Nucleosides
Voss, James J. De,Hangeland, Jon J.,Townsend, Craig A.
, p. 2715 - 2723 (1994)
Starting from D-(-)-ribose, a set of synthetic routes sharing common intermediates has been developed and exemplified in -, -, -, (5'R)--, and (5'S)--N4-benzoylcytidine and, by deoxygenation, their corresponding 2'-deoxynucleosides.These syntheses provide convenient access to millimolar quantities of deuterium/tritium-labeled natural or unnatural nucleosides for direct use or automated oligonucleotide synthesis.
